Reactome | IGFBP2 binds IGF forming IGF:IGFBP2

IGFBP2 binds IGF forming IGF:IGFBP2

Stable Identifier

R-HSA-381412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

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IGFBP 2 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 2. IGFBP 2 is enriched in cerebrospinal fluid and inhibits IGF function. IGFBP 2 is not significantly degraded in circulation.

Literature References

PubMed ID	Title	Journal	Year
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM	J Biol Chem	1993
7543116	Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation Juul, A, Dalgaard, P, Blum, WF, Bang, P, Hall, K, Michaelsen, KF, Müller, J, Skakkebaek, NE	J Clin Endocrinol Metab	1995
11751371	Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Hoeflich, A, Reisinger, R, Lahm, H, Kiess, W, Blum, WF, Kolb, HJ, Weber, MM, Wolf, E	Cancer Res	2001
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
17985932	Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding Kuang, Z, Yao, S, McNeil, KA, Thompson, JA, Bach, LA, Forbes, BE, Wallace, JC, Norton, RS	Biochemistry	2007
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM	Experientia	1993
2479552	Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) Binkert, C, Landwehr, J, Mary, JL, Schwander, J, Heinrich, G	EMBO J	1989
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Parker, A, Busby W, Jr, Clemmons, DR	J Biol Chem	1994
10912521	Effects of IGFBP-2 overexpression in vitro and in vivo Wolf, E, Lahm, H, Wu, M, Wanke, R, Hoeflich, A	Pediatr Nephrol	2000