Reactome | IGFBP2 binds IGF forming IGF:IGFBP2

IGFBP2 binds IGF forming IGF:IGFBP2

Stable Identifier

R-HSA-381412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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IGFBP 2 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 2. IGFBP 2 is enriched in cerebrospinal fluid and inhibits IGF function. IGFBP 2 is not significantly degraded in circulation.

Literature References

PubMed ID	Title	Journal	Year
7543116	Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation Hall, K, Skakkebaek, NE, Müller, J, Blum, WF, Michaelsen, KF, Bang, P, Dalgaard, P, Juul, A	J Clin Endocrinol Metab	1995
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF	J Biol Chem	1993
11751371	Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Weber, MM, Reisinger, R, Blum, WF, Wolf, E, Kiess, W, Lahm, H, Hoeflich, A, Kolb, HJ	Cancer Res	2001
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
17985932	Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding Thompson, JA, Kuang, Z, Norton, RS, Wallace, JC, Forbes, BE, Bach, LA, Yao, S, McNeil, KA	Biochemistry	2007
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S	Experientia	1993
2479552	Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) Schwander, J, Binkert, C, Mary, JL, Heinrich, G, Landwehr, J	EMBO J	1989
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Busby W, Jr, Parker, A, Clemmons, DR	J Biol Chem	1994
10912521	Effects of IGFBP-2 overexpression in vitro and in vivo Wolf, E, Wanke, R, Lahm, H, Hoeflich, A, Wu, M	Pediatr Nephrol	2000