IGFBP2 binds IGF forming IGF:IGFBP2

Stable Identifier
Reaction [binding]
Homo sapiens
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IGFBP 2 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 2. IGFBP 2 is enriched in cerebrospinal fluid and inhibits IGF function. IGFBP 2 is not significantly degraded in circulation.

Literature References
PubMed ID Title Journal Year
7543116 Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

Hall, K, Skakkebaek, NE, Müller, J, Blum, WF, Michaelsen, KF, Bang, P, Dalgaard, P, Juul, A

J Clin Endocrinol Metab 1995
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF

J Biol Chem 1993
11751371 Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

Weber, MM, Reisinger, R, Blum, WF, Wolf, E, Kiess, W, Lahm, H, Hoeflich, A, Kolb, HJ

Cancer Res 2001
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
17985932 Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding

Thompson, JA, Kuang, Z, Norton, RS, Wallace, JC, Forbes, BE, Bach, LA, Yao, S, McNeil, KA

Biochemistry 2007
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S

Experientia 1993
2479552 Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)

Schwander, J, Binkert, C, Mary, JL, Heinrich, G, Landwehr, J

EMBO J 1989
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Busby W, Jr, Parker, A, Clemmons, DR

J Biol Chem 1994
10912521 Effects of IGFBP-2 overexpression in vitro and in vivo

Wolf, E, Wanke, R, Lahm, H, Hoeflich, A, Wu, M

Pediatr Nephrol 2000
Orthologous Events
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