Reactome | IGFBP2 binds IGF forming IGF:IGFBP2

IGFBP2 binds IGF forming IGF:IGFBP2

Stable Identifier

R-HSA-381412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

IGFBP 2 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 2. IGFBP 2 is enriched in cerebrospinal fluid and inhibits IGF function. IGFBP 2 is not significantly degraded in circulation.

Literature References

PubMed ID	Title	Journal	Year
7543116	Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation Juul, A, Dalgaard, P, Blum, WF, Bang, P, Hall, K, Michaelsen, KF, Müller, J, Skakkebaek, NE	J Clin Endocrinol Metab	1995
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM	J Biol Chem	1993
11751371	Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Hoeflich, A, Reisinger, R, Lahm, H, Kiess, W, Blum, WF, Kolb, HJ, Weber, MM, Wolf, E	Cancer Res	2001
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
17985932	Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding Kuang, Z, Yao, S, McNeil, KA, Thompson, JA, Bach, LA, Forbes, BE, Wallace, JC, Norton, RS	Biochemistry	2007
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM	Experientia	1993
2479552	Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) Binkert, C, Landwehr, J, Mary, JL, Schwander, J, Heinrich, G	EMBO J	1989
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Parker, A, Busby W, Jr, Clemmons, DR	J Biol Chem	1994
10912521	Effects of IGFBP-2 overexpression in vitro and in vivo Wolf, E, Lahm, H, Wu, M, Wanke, R, Hoeflich, A	Pediatr Nephrol	2000