IGFBP2 binds IGF forming IGF:IGFBP2

Stable Identifier
R-HSA-381412
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IGFBP 2 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 2. IGFBP 2 is enriched in cerebrospinal fluid and inhibits IGF function. IGFBP 2 is not significantly degraded in circulation.

Literature References
PubMed ID Title Journal Year
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM

J Biol Chem 1993
7543116 Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

Juul, A, Dalgaard, P, Blum, WF, Bang, P, Hall, K, Michaelsen, KF, Müller, J, Skakkebaek, NE

J Clin Endocrinol Metab 1995
11751371 Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

Hoeflich, A, Reisinger, R, Lahm, H, Kiess, W, Blum, WF, Kolb, HJ, Weber, MM, Wolf, E

Cancer Res 2001
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
17985932 Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding

Kuang, Z, Yao, S, McNeil, KA, Thompson, JA, Bach, LA, Forbes, BE, Wallace, JC, Norton, RS

Biochemistry 2007
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM

Experientia 1993
2479552 Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)

Binkert, C, Landwehr, J, Mary, JL, Schwander, J, Heinrich, G

EMBO J 1989
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Parker, A, Busby W, Jr, Clemmons, DR

J Biol Chem 1994
10912521 Effects of IGFBP-2 overexpression in vitro and in vivo

Wolf, E, Lahm, H, Wu, M, Wanke, R, Hoeflich, A

Pediatr Nephrol 2000
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