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About
What is Reactome ?
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EP300 [nucleoplasm]
Stable Identifier
R-HSA-381325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p300, Histone acetyltransferase p300, EP300_HUMAN, KAT3B
Icon
Locations in the PathwayBrowser for interactor UniProt:Q96KQ4 PPP1R13B
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 binds CDC25A promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)
Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Circadian Clock (Homo sapiens)
RORA activates gene expression (Homo sapiens)
RORA, EP300 bind CPT1A gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RORA, EP300 bind SREBF1 gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RORA, EP300 bind NPAS2 gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA4 chromatin (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Zygotic genome activation (ZGA) (Homo sapiens)
DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
B-WICH complex positively regulates rRNA expression (Homo sapiens)
B-WICH recruits histone acetyltransferases (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
BRD7 binds TP53 and EP300 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
PI5P Regulates TP53 Acetylation (Homo sapiens)
ING2 recruits EP300 to TP53 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
JMY, TTC5 and EP300 bind (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1:CBFB binds EP300 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates p14-ARF (Homo sapiens)
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
RUNX3 binds EP300 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
SMURFs ubiquitinate RUNX3 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
Activation of the TFAP2 (AP-2) family of transcription factors (Homo sapiens)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of EP300 with SUMO1 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NICD1 is phosphorylated by CDK8 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 intracellular domain regulates transcription (Homo sapiens)
NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
EP300 is recruited to MYC and BCL2 genes (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
HATs and coactivators are recruited to the CTSD gene (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
p-Y705,S727 STAT3 is acetylated (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)
EP300 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q09472 EP300
Gene Names
EP300, P300
Chain
initiator methionine:, chain:2-2414
Reference Genes
BioGPS Gene:2033 EP300
COSMIC (genes):EP300 EP300
CTD Gene:2033 EP300
dbSNP Gene:2033 EP300
ENSEMBL:ENSG00000100393 EP300
ENSEMBL_homo_sapiens_GENE:ENSG00000100393.15 EP300
HGNC:3373 EP300
KEGG Gene (Homo sapiens):2033 EP300
Monarch:2033 EP300
NCBI Gene:2033 EP300
OMIM:602700 EP300
UCSC:Q09472 EP300
Reference Transcript
RefSeq:NM_001429.3 EP300
Other Identifiers
11725127_at
16930534
17119320
202221_PM_s_at
202221_s_at
2033
213579_PM_s_at
213579_s_at
33896_at
3946616
3946617
3946618
3946619
3946627
3946629
3946631
3946632
3946634
3946637
3946638
3946640
3946641
3946642
3946643
3946645
3946646
3946649
3946651
3946652
3946653
3946655
3946656
3946657
3946658
3946660
3946665
3946667
3946669
3946671
3946672
3946673
3946674
3946675
3946676
3946677
3946678
3946679
3946682
3946683
3946684
3946685
3946686
3946687
3946688
3946689
3946690
3946691
551_at
8073345
A_14_P108084
A_14_P127141
A_23_P40693
A_24_P7887
GE58850
GO:0000122
GO:0000123
GO:0000785
GO:0001221
GO:0001223
GO:0001666
GO:0001756
GO:0001966
GO:0002039
GO:0002209
GO:0002223
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003712
GO:0003713
GO:0003723
GO:0003824
GO:0004402
GO:0004468
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0005975
GO:0006091
GO:0006110
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006473
GO:0006475
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007005
GO:0007049
GO:0007249
GO:0007399
GO:0007507
GO:0007519
GO:0007611
GO:0007623
GO:0008013
GO:0008092
GO:0008270
GO:0009887
GO:0010484
GO:0010485
GO:0010506
GO:0010507
GO:0010628
GO:0010742
GO:0010821
GO:0010976
GO:0012501
GO:0016407
GO:0016573
GO:0016740
GO:0016746
GO:0016922
GO:0018076
GO:0018393
GO:0018394
GO:0023052
GO:0030154
GO:0030183
GO:0030220
GO:0030324
GO:0030511
GO:0031333
GO:0031490
GO:0031648
GO:0031669
GO:0032991
GO:0032993
GO:0034212
GO:0034644
GO:0035264
GO:0035855
GO:0036211
GO:0036268
GO:0042307
GO:0042771
GO:0043226
GO:0043627
GO:0043923
GO:0043993
GO:0044013
GO:0044017
GO:0044877
GO:0045444
GO:0045721
GO:0045815
GO:0045893
GO:0045944
GO:0046427
GO:0046872
GO:0048156
GO:0048511
GO:0048856
GO:0050681
GO:0050821
GO:0050877
GO:0050896
GO:0051059
GO:0051091
GO:0051604
GO:0055086
GO:0060325
GO:0060765
GO:0061629
GO:0061733
GO:0061920
GO:0061921
GO:0065003
GO:0071233
GO:0090043
GO:0097157
GO:0097677
GO:0098542
GO:0106226
GO:0120300
GO:0120301
GO:0140033
GO:0140064
GO:0140065
GO:0140066
GO:0140067
GO:0140068
GO:0140069
GO:0140096
GO:0140110
GO:0140297
GO:0140908
GO:1900034
GO:1901135
GO:1901796
GO:1904263
HMNXSV003052530
Hs.25272.0.A2_3p_a_at
Hs.25272.1.A1_3p_a_at
ILMN_1744665
PH_hs_0023353
PH_hs_0032399
TC22000332.hg
U01877_at
Participates
as a component of
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] (Homo sapiens)
BLC2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Homo sapiens)
ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Homo sapiens)
MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm] (Homo sapiens)
TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
FOXA1:GATA3:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
CITED1:EP300:ESR1:estrogen:TGFA gene promoter [nucleoplasm] (Homo sapiens)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Homo sapiens)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Homo sapiens)
MYSM1:EP300:KAT2B [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
DUX4:TPRXL:TPRX1:TPRX2:EP300:CREBBP:ZSCAN4 gene [nucleoplasm] (Homo sapiens)
CEBPE gene:EP300:SPI1:PML [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] (Homo sapiens)
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:EP300 [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
NOTCH2 coactivator complex:p-S133-CREB1:EP300:GZMB Gene [nucleoplasm] (Homo sapiens)
xNOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
RUNX3:CBFB:EP300 [nucleoplasm] (Homo sapiens)
Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm] (Homo sapiens)
mNICD1 Chimeric Enhancer Complex [nucleoplasm] (Homo sapiens)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Homo sapiens)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Homo sapiens)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-T611,S730,S739-FOXM1:EP300:CDC25A Gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
(2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
ID1,ID3 genes:p-S133-CREB1:LYL1:EP300 [nucleoplasm] (Homo sapiens)
VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] (Homo sapiens)
HIF:CBP:p300 [nucleoplasm] (Homo sapiens)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
as an input of
NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)
GREB1 binds ESR1:ESTG and co-activators (Homo sapiens)
HATs and coactivators are recruited to the CTSD gene (Homo sapiens)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)
ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)
CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Homo sapiens)
NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)
EP300 is recruited to MYC and BCL2 genes (Homo sapiens)
SUMOylation of EP300 with SUMO1 (Homo sapiens)
B-WICH recruits histone acetyltransferases (Homo sapiens)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene (Homo sapiens)
SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
Retinoic acid activates HOXA4 chromatin (Homo sapiens)
RORA, EP300 bind CPT1A gene (Homo sapiens)
RORA, EP300 bind SREBF1 gene (Homo sapiens)
SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
EP300 binds SOH-C477-Foxo4 (Mus musculus)
RUNX1:CBFB binds EP300 (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter (Homo sapiens)
RUNX3 binds EP300 (Homo sapiens)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)
JMY, TTC5 and EP300 bind (Homo sapiens)
BRD7 binds TP53 and EP300 (Homo sapiens)
FOXM1 binds CDC25A promoter (Homo sapiens)
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
RORA, EP300 bind NPAS2 gene (Homo sapiens)
NICD1 in complex with RBPJ (CSL) recruits MAML (Homo sapiens)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes (Homo sapiens)
p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)
Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)
RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)
ING2 recruits EP300 to TP53 (Homo sapiens)
as an output of
CDK8 phosphorylates NICD1 PEST domain mutants (Homo sapiens)
EP300 acetylates Foxo4 (Homo sapiens)
TXN disrupts Foxo4 comples with EP300 (Homo sapiens)
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
CDK8 phosphorylates xNICD1 (Homo sapiens)
NICD1 is phosphorylated by CDK8 (Homo sapiens)
CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)
as a member of
histone acetyltransferases [nucleoplasm] (Homo sapiens)
CREBBP,EP300 [nucleoplasm] (Homo sapiens)
as a candidate of
KAT2B,(EP300) [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
SMURFs ubiquitinate RUNX3
(Homo sapiens)
Other forms of this molecule
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
Foxo4-S-S-EP300 [nucleoplasm]
FOXO4-S-S-EP300 [nucleoplasm]
p-S,T-EP300 [nucleoplasm]
Inferred To
Ep300 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of EP300 [nucleoplasm]
(Danio rerio)
Ghost homologue of EP300 [nucleoplasm]
(Dictyostelium discoideum)
EP300 [nucleoplasm]
(Bos taurus)
EP300 [nucleoplasm]
(Caenorhabditis elegans)
EP300 [nucleoplasm]
(Canis familiaris)
EP300 [nucleoplasm]
(Gallus gallus)
EP300 [nucleoplasm]
(Mus musculus)
EP300 [nucleoplasm]
(Sus scrofa)
ep300 [nucleoplasm]
(Xenopus tropicalis)
nej [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001420.2
Guide to Pharmacology - Targets
2735
OpenTargets
ENSG00000100393
ZINC - Substances
EP300_HUMAN
ZINC - Biogenic
EP300_HUMAN
ZINC target
Q09472
PRO
Q09472
PDB
4PZT
,
7LJE
,
1L3E
,
6V90
,
4PZS
,
6V8N
,
7QGS
,
8HAH
,
8HAI
,
4PZR
,
2MZD
,
8FVF
,
3IO2
,
8HAG
,
6PGU
,
5LKU
,
5NU5
,
5LKT
,
3P57
,
3T92
,
7UGI
,
8HAK
,
7VI0
,
6K4N
,
7W9V
,
8HAJ
,
7VHY
,
5KJ2
,
7VHZ
,
5BT3
,
5LKZ
,
2K8F
,
6FGS
,
6GYT
,
1P4Q
,
6PF1
,
6V8K
,
7SSK
,
4BHW
,
6GYR
,
5LKX
,
8E1D
,
6FGN
,
8GZC
,
6V8B
,
7SS8
,
7SZQ
,
5XZC
,
2MH0
,
7XFG
,
3I3J
,
3BIY
,
7XEZ
,
6DS6
,
5LPM
,
5LPK
ZINC - Metabolites
EP300_HUMAN
HPA
ENSG00000100393-EP300
GeneCards
Q09472
Ensembl
ENSP00000263253
,
ENSG00000100393
,
ENST00000263253
Pharos - Targets
Q09472
Orphanet
15982
ZINC - Predictions - Purchasable
EP300_HUMAN
HMDB Protein
HMDBP00011
Interactors (61)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.976
22
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.962
20
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.784
7
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.734
4
UniProt:P27695 APEX1
1
APEX1 [nucleoplasm]
(R-HSA-50119)
0.724
8
UniProt:P03255 E1A
0.702
3
UniProt:P03255-2
0.702
3
UniProt:Q8WXX7 AUTS2
1
AUTS2 [nucleoplasm]
(R-HSA-8937967)
0.677
6
UniProt:Q6ZUJ4 CC062
0.671
5
UniProt:Q9QXM1
2
Jmy [nucleoplasm]
(R-MMU-6804247)
Jmy [nucleoplasm]
(R-MMU-6804234)
0.66
16
UniProt:P06790 VE2
0.658
6
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.658
4
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.653
3
UniProt:P03259 E1A
0.646
3
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.623
5
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.61
4
UniProt:P03126 VE6
0.602
8
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
0.602
4
UniProt:P20265 POU3F2
1
POU3F2 [nucleoplasm]
(R-HSA-9613754)
0.602
3
UniProt:O60934 NBN
3
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
NBN [cytosol]
(R-HSA-5684005)
NBN [nucleoplasm]
(R-HSA-75163)
0.602
5
UniProt:P03129 VE7
0.593
14
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.591
4
UniProt:Q9NPI1 BRD7
1
BRD7 [nucleoplasm]
(R-HSA-3222092)
0.591
3
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.576
3
UniProt:Q01844 EWS
0.573
2
UniProt:P61201 COPS2
2
COPS2 [cytosol]
(R-HSA-416971)
COPS2 [nucleoplasm]
(R-HSA-5697012)
0.558
2
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.558
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.553
2
UniProt:P11473 VDR
2
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
VDR [nucleoplasm]
(R-HSA-375512)
0.547
3
UniProt:P55209 NP1L1
0.544
3
UniProt:P06422 VE2
0.544
7
UniProt:Q08369 Gata4
2
Gata4 [nucleoplasm]
(R-MMU-9692183)
Gata4 [nucleoplasm]
(R-MMU-400553)
0.544
2
UniProt:Q9Y6Q9 NCOA3
2
NCOA3 [nucleoplasm]
(R-HSA-442488)
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
0.536
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.536
2
UniProt:Q9Y463 DYR1B
0.527
2
IntAct:EBI-1550784 CDKN1A
0.527
3
IntAct:EBI-1776214 KLK3
0.527
2
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.527
3
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.527
2
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
2
UniProt:P29279 CTGF
1
CTGF [extracellular region]
(R-HSA-561148)
0.527
2
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
3
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.525
3
UniProt:K4P3M7 K4P3M7
0.524
4
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.524
3
UniProt:P56279 TCL1A
0.524
4
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
2
UniProt:P05549 TFAP2A
1
TFAP2A [nucleoplasm]
(R-HSA-8864280)
0.508
7
UniProt:Q99967 CITED2
1
CITED2 [nucleoplasm]
(R-HSA-6804489)
0.508
3
UniProt:Q13625 TP53BP2
1
TP53BP2 [nucleoplasm]
(R-HSA-6799780)
0.499
2
UniProt:P03070 LT
0.499
2
UniProt:Q9UL17 TBX21
0.499
5
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.499
2
UniProt:Q61221
7
Hif1a [cytosol]
(R-MMU-1234110)
Hif1a [nucleoplasm]
(R-MMU-1234105)
Hif1a [cytosol]
(R-MMU-1234131)
phospho-Hif1a [cytosol]
(R-MMU-9634700)
phospho-Hif1a [cytosol]
(R-MMU-8857584)
Hif1a [cytosol]
(R-MMU-1234102)
Hif1a [nucleoplasm]
(R-MMU-1234135)
0.499
2
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.499
2
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.488
2
UniProt:P06930 VE6
0.462
2
UniProt:P06428 VE6
0.462
2
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [specific granule lumen]
(R-HSA-6799611)
0.462
2
UniProt:Q9P0U4 CXXC1
1
CXXC1 [nucleoplasm]
(R-HSA-535610)
0.462
2
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