PPARG:RXRA heterodimer binds to PPARG corepressors

Stable Identifier
R-HSA-381290
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PPARG:RXRA heterodimer binds to PPARG corepressors
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The PPARG:RXRA heterodimer binds specific the PPRE element, two 6-bp DR-1 motifs separated by 1 nucleotide, in the promoters of target genes such as aP2/FABP4 even in the absence of fatty acid ligands that activate PPARG. When activating ligands of PPARG are absent PPARG:RXRA recruits corepressors such as NCoR2(SMRT), NCoR, and HDAC3 to maintain the target gene in an inactive state.
Literature References
PubMed ID Title Journal Year
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
8970730 Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology

Wahli, W, Desvergne, B, Lemberger, T

Annu Rev Cell Dev Biol 1996
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Inferred From
Pparg:Rxra heterodimer binds to PPARG corepressors (Mus musculus)
Authored
May, B  (2009-05-15)
Reviewed
Sethi, JK  (2011-02-10)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2008-11-20)
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