Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
STK11 [cytosol]
Stable Identifier
R-HSA-380954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LKB1
Locations in the PathwayBrowser for interactor UniProt:Q13098 GPS1
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
STK11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15831 STK11
Gene Names
STK11, LKB1, PJS
Chain
chain:1-430, propeptide:431-433
Reference Genes
BioGPS Gene:6794 STK11
COSMIC (genes):STK11 STK11
CTD Gene:6794 STK11
dbSNP Gene:6794 STK11
ENSEMBL:ENSG00000118046 STK11
HGNC:11389 STK11
KEGG:hsa:6794 STK11
Monarch:6794 STK11
NCBI Gene:6794 STK11
OMIM:602216 STK11
UCSC:Q15831 STK11
Reference Transcript
RefSeq:XM_005259618.3 STK11
RefSeq:NM_000455.4 STK11
Other Identifiers
11735699_x_at
16856463
204292_PM_x_at
204292_x_at
231017_PM_at
231017_at
3815568
3815569
3815570
3815571
3815572
3815579
3815580
3815581
3815582
3815586
3815588
3815589
3815591
3815592
3815593
3815594
3815595
3815596
3815597
3815598
3815599
3815600
3815601
3815602
3815603
3815604
3815605
41657_PM_at
41657_at
6794
74967_at
8024204
86312_at
A_23_P16483
A_24_P159866
A_33_P3389148
GE60471
GO:0000287
GO:0001558
GO:0001894
GO:0001944
GO:0002039
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006468
GO:0006470
GO:0006914
GO:0006915
GO:0006974
GO:0007163
GO:0007165
GO:0007283
GO:0007409
GO:0008285
GO:0010212
GO:0010508
GO:0012501
GO:0014823
GO:0016020
GO:0016740
GO:0018107
GO:0022414
GO:0030010
GO:0030018
GO:0030111
GO:0030154
GO:0030275
GO:0030295
GO:0030308
GO:0030511
GO:0032147
GO:0032991
GO:0033762
GO:0033993
GO:0034504
GO:0042593
GO:0043226
GO:0043276
GO:0043434
GO:0044877
GO:0045059
GO:0045722
GO:0046777
GO:0046872
GO:0048814
GO:0048856
GO:0050772
GO:0050852
GO:0051645
GO:0051726
GO:0051896
GO:0060767
GO:0060770
GO:0070062
GO:0070314
GO:0071493
GO:0072332
GO:0090090
GO:0097066
GO:0097484
GO:0098772
GO:0106310
GO:0120163
GO:0140096
GO:0140535
GO:1900182
GO:1901610
GO:1901796
GO:1902554
GO:1904262
HMNXSV003049229
HMNXSV003056543
Hs.155647.0.S1_3p_at
ILMN_1751871
PH_hs_0015564
PH_hs_0039557
TC19001930.hg
TC19002617.hg
g4507270_3p_s_at
Participates
as an input of
LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)
as a component of
LKB1:STRAD:MO25 [cytosol] (Homo sapiens)
Other forms of this molecule
STK11 [nucleoplasm]
Inferred To
STK11 [cytosol]
(Bos taurus)
STK11 [cytosol]
(Canis familiaris)
STK11 [cytosol]
(Gallus gallus)
STK11 [cytosol]
(Mus musculus)
STK11 [cytosol]
(Rattus norvegicus)
STK11 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_000446.1
,
XP_005259675.1
ZINC - World Drugs
STK11_HUMAN
Guide to Pharmacology - Targets
2212
ENSEMBL
ENSP00000324856
,
ENSP00000490268
,
ENSP00000498804
,
ENST00000652231
,
ENST00000326873
,
ENST00000585465
OpenTargets
ENSG00000118046
ZINC - FDA approved
STK11_HUMAN
ZINC - Substances
STK11_HUMAN
ZINC - Biogenic
STK11_HUMAN
ZINC target
Q15831
PRO
Q15831
GlyGen
Q15831
PDB
2WTK
,
5WXN
,
4ZDR
ZINC - Investigational
STK11_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000118046-STK11
Pharos - Targets
Q15831
Orphanet
STK11
ZINC - Predictions - Purchasable
STK11_HUMAN
HMDB Protein
HMDBP01530
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7RTN6 STRADA
1
STRADA [cytosol]
(R-HSA-380960)
0.953
22
UniProt:Q9Y376 CAB39
4
CAB39 [ficolin-1-rich granule lumen]
(R-HSA-6801287)
CAB39 [extracellular region]
(R-HSA-6806462)
CAB39 [secretory granule lumen]
(R-HSA-6801288)
CAB39 [cytosol]
(R-HSA-380969)
0.941
22
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.899
10
UniProt:Q9C0K7 STRADB
1
STRADB [cytosol]
(R-HSA-380976)
0.89
13
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.848
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.784
8
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.744
6
UniProt:Q9UNS2 COPS3
2
COPS3 [nucleoplasm]
(R-HSA-5697017)
COPS3 [cytosol]
(R-HSA-416973)
0.725
4
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.683
5
UniProt:Q9BT78 COPS4
2
COPS4 [nucleoplasm]
(R-HSA-5697020)
COPS4 [cytosol]
(R-HSA-416965)
0.669
4
UniProt:P48426 PIP4K2A
2
PIP4K2A [cytosol]
(R-HSA-1604641)
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
0.643
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.61
6
UniProt:Q7RTN6-1 STRADA
0.564
3
UniProt:P36952 SPB5
0.547
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.544
2
UniProt:Q9NNW5 WDR6
1
WDR6 [cytosol]
(R-HSA-9715165)
0.543
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.536
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:Q7Z6I8 CE024
0.527
2
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.527
2
UniProt:P26440 IVD
16
IVD [mitochondrial matrix]
(R-HSA-70729)
R398Q IVD [mitochondrial matrix]
(R-HSA-9914799)
I379T IVD [mitochondrial matrix]
(R-HSA-9914797)
Y403N IVD [mitochondrial matrix]
(R-HSA-9914808)
D72N IVD [mitochondrial matrix]
(R-HSA-9914807)
V374A IVD [mitochondrial matrix]
(R-HSA-9914806)
R53P IVD [mitochondrial matrix]
(R-HSA-9914805)
G123R IVD [mitochondrial matrix]
(R-HSA-9914804)
R395C IVD [mitochondrial matrix]
(R-HSA-9914803)
M332T IVD [mitochondrial matrix]
(R-HSA-9914802)
A314V IVD [mitochondrial matrix]
(R-HSA-9914801)
L45P IVD [mitochondrial matrix]
(R-HSA-9914800)
R414L IVD [mitochondrial matrix]
(R-HSA-9914796)
T239I IVD [mitochondrial matrix]
(R-HSA-9914795)
R340Q IVD [mitochondrial matrix]
(R-HSA-9914810)
C360R IVD [mitochondrial matrix]
(R-HSA-9914809)
0.527
2
UniProt:Q9H9S4 CAB39L
1
CAB39L [cytosol]
(R-HSA-380977)
0.527
2
UniProt:Q13098 GPS1
2
GPS1 [cytosol]
(R-HSA-416972)
GPS1 [nucleoplasm]
(R-HSA-5697010)
0.527
2
UniProt:Q99627 COPS8
2
COPS8 [cytosol]
(R-HSA-416962)
COPS8 [nucleoplasm]
(R-HSA-5697014)
0.527
2
UniProt:O75164 KDM4A
2
KDM4A [nucleoplasm]
(R-HSA-351646)
K48PolyUb-KDM4A [nucleoplasm]
(R-HSA-5683049)
0.527
3
UniProt:P61201 COPS2
2
COPS2 [cytosol]
(R-HSA-416971)
COPS2 [nucleoplasm]
(R-HSA-5697012)
0.527
2
UniProt:Q15018 FAM175B
1
FAM175B [cytosol]
(R-HSA-5691428)
0.527
3
UniProt:Q58FF7 H90B3
0.527
2
UniProt:Q58FF6 H90B4
0.527
3
UniProt:Q58FG0 HS905
0.527
4
UniProt:Q58FG1 HS904
0.527
4
UniProt:P26927 MST1
3
MST1(19-483) [extracellular region]
(R-HSA-6800207)
MST1(484-711) [extracellular region]
(R-HSA-6800230)
pro-MST1 [extracellular region]
(R-HSA-6800227)
0.499
2
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.499
2
UniProt:Q8TEW0 PARD3
3
PARD3 [cell junction]
(R-HSA-2134481)
PARD3 [cytosol]
(R-HSA-419993)
PARD3 [plasma membrane]
(R-HSA-419980)
0.463
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text