5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid

Stable Identifier
R-HSA-380608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

5-hydroxyindole acetaldehyde is then catalyzed by aldehyde dehydrogenase to form 5-hydroxyindole acetic acid

Literature References
PubMed ID Title Journal Year
8778744 Changes in serotonin metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide

Beck, O, Helander, A, Carlsson, S, Borg, S

Pharmacol Toxicol 1995
17010132 Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice

Fernández, E, Koek, W, Ran, Q, Gerhardt, GA, France, CP, Strong, R

Alcohol Clin Exp Res 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase (NAD+) activity of ALDH2 tetramer [mitochondrial matrix]
Physical Entity
ALDH2 tetramer [mitochondrial matrix]
Activity
aldehyde dehydrogenase (NAD+) activity (0004029)
Orthologous Events
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Bos taurus)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Canis familiaris)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Danio rerio)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Drosophila melanogaster)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)
5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-11-13)
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