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Association of NuMA with microtubules
Stable Identifier
R-HSA-380316
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Association of NuMA with microtubules (Homo sapiens)
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NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al. 1996, Gueth-Hallonet et al.1998, Harborth et al.1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains.
Literature References
PubMed ID
Title
Journal
Year
11956313
Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules
Haren, L
,
Merdes, A
J Cell Sci
2002
Participants
Input
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol]
(Homo sapiens)
Microtubule [cytosol]
(Homo sapiens)
Output
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol]
(Homo sapiens)
Participates
as an event of
Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
Orthologous Events
Association of NuMA with microtubules (Bos taurus)
Association of NuMA with microtubules (Canis familiaris)
Association of NuMA with microtubules (Mus musculus)
Association of NuMA with microtubules (Rattus norvegicus)
Association of NuMA with microtubules (Sus scrofa)
Association of NuMA with microtubules (Xenopus tropicalis)
Authored
Matthews, L (2008-11-11)
Reviewed
Merdes, A (2008-11-17)
Created
Matthews, L (2008-11-11)
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