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Recruitment of Plk1 to centrosomes
Stable Identifier
R-HSA-380311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Centrosome maturation (Homo sapiens)
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
Recruitment of Plk1 to centrosomes (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007).
Literature References
PubMed ID
Title
Journal
Year
7790358
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
Fry, AM
,
Golsteyn, RM
,
Nigg, EA
,
Mundt, KE
J Cell Biol
1995
Participants
Input
centrosome [cytosol]
(Homo sapiens)
PLK1 [cytosol]
(Homo sapiens)
Output
Centrosome associated Plk1 [cytosol]
(Homo sapiens)
Participates
as an event of
Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
This event is regulated
Positively by
Regulator
CDK11p58 [cytosol]
(Homo sapiens)
Orthologous Events
Recruitment of Plk1 to centrosomes (Bos taurus)
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Recruitment of Plk1 to centrosomes (Gallus gallus)
Recruitment of Plk1 to centrosomes (Mus musculus)
Recruitment of Plk1 to centrosomes (Rattus norvegicus)
Recruitment of Plk1 to centrosomes (Sus scrofa)
Recruitment of Plk1 to centrosomes (Xenopus tropicalis)
Authored
Matthews, L (2008-11-11)
Reviewed
Merdes, A (2008-11-17)
Created
Matthews, L (2008-11-11)
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