Recruitment of Plk1 to centrosomes

Stable Identifier
R-HSA-380311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007).

Literature References
PubMed ID Title Journal Year
7790358 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

Golsteyn, RM, Mundt, KE, Fry, AM, Nigg, EA

J Cell Biol 1995
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