Recruitment of Plk1 to centrosomes

Stable Identifier
R-HSA-380311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Recruitment of Plk1 to centrosomes
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Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007).
Literature References
PubMed ID Title Journal Year
7790358 Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

Fry, AM, Golsteyn, RM, Nigg, EA, Mundt, KE

J Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CDK11p58 [cytosol] (Homo sapiens)
Orthologous Events
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Recruitment of Plk1 to centrosomes (Canis familiaris)
Recruitment of Plk1 to centrosomes (Gallus gallus)
Recruitment of Plk1 to centrosomes (Mus musculus)
Recruitment of Plk1 to centrosomes (Rattus norvegicus)
Recruitment of Plk1 to centrosomes (Sus scrofa)
Recruitment of Plk1 to centrosomes (Xenopus tropicalis)
Authored
Matthews, L  (2008-11-11)
Reviewed
Merdes, A  (2008-11-17)
Created
Matthews, L  (2008-11-11)
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