Reactome | CEP78 [cytosol]

CEP78 [cytosol]

Stable Identifier

R-HSA-380304

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep78

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP78 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q5JTW2 CEP78

Gene Names

CEP78, C9orf81

Chain

chain:1-689

Reference Genes

BioGPS Gene:84131 CEP78

COSMIC (genes):CEP78 CEP78

CTD Gene:84131 CEP78

dbSNP Gene:84131 CEP78

ENSEMBL:ENSG00000148019 CEP78

ENSEMBL:ENSG00000148019.14 CEP78

HGNC:25740 CEP78

KEGG Gene (Homo sapiens):84131 CEP78

Monarch:84131 CEP78

NCBI Gene:84131 CEP78

OMIM:617110 CEP78

UCSC:Q5JTW2 CEP78

Reference Transcript

Other Identifiers

11725011_a_at

11760390_at

1557985_PM_s_at

1557985_s_at

17086167

228774_PM_at

228774_at

235919_PM_at

235919_at

3170086

3170087

3175930

3175931

3175933

3175934

3175935

3175936

3175937

3175938

3175941

3175942

3175943

3175946

3175947

3175948

3175949

3175950

3175951

3175952

3175953

3175954

3175955

3175956

3175957

3175961

3175963

3175965

3175967

43122_at

61314_at

77388_at

8156026

84131

A_23_P353436

A_32_P34404

A_33_P3219641

GE470283

GE84528

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0030030

GO:0036064

GO:0042995

GO:0043226

GO:0044782

HMNXSV003054311

Hs.187621.0.A1_3p_at

Hs.50421.1.A1_3p_at

Hs.50421.1.A1_3p_s_at

PH_hs_0018135

RNA147058|p0162_imsncRNA254

TC09000357.hg

Participates

as a component of

Inferred To

cep78 [cytosol] (Xenopus tropicalis)

Cep78 [cytosol] (Mus musculus)

Cep78 [cytosol] (Rattus norvegicus)

CEP78 [cytosol] (Bos taurus)

CEP78 [cytosol] (Canis familiaris)

CEP78 [cytosol] (Danio rerio)

CEP78 [cytosol] (Gallus gallus)

CEP78 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001317622.1, NP_001092272.1, NP_001317623.1, NP_115547.1, NP_001317620.1

OpenTargets

ENSG00000148019

HPA

ENSG00000148019-CEP78

GeneCards

Q5JTW2

Ensembl

ENSG00000148019, ENSP00000411284, ENSP00000496423, ENST00000415759, ENST00000424347, ENST00000376597, ENSP00000399286, ENST00000643273, ENST00000642669, ENSP00000495681, ENSP00000365782

PRO

Q5JTW2

Pharos - Targets

Q5JTW2

Orphanet

25499

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