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Dissociation of Phospho-Nlp from the centrosome
Stable Identifier
R-HSA-380303
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Centrosome maturation (Homo sapiens)
Loss of proteins required for interphase microtubule organization from the centrosome (Homo sapiens)
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mitotic activation of Plk1 is required for efficient displacement of Nlp from the centrosome (Casenghi et al., 2003).
Literature References
PubMed ID
Title
Journal
Year
12852856
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation
Duncan, PI
,
Nigg, EA
,
Weinhart, U
,
Casenghi, M
,
Körner, R
,
Meraldi, P
Dev Cell
2003
Participants
Input
centrosome containing phosphorylated Nlp [cytosol]
(Homo sapiens)
Output
Nlp-depleted centrosome [cytosol]
(Homo sapiens)
p-NINL [cytosol]
(Homo sapiens)
Participates
as an event of
Loss of Nlp from mitotic centrosomes (Homo sapiens)
Orthologous Events
Dissociation of Phospho-Nlp from the centrosome (Bos taurus)
Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)
Dissociation of Phospho-Nlp from the centrosome (Mus musculus)
Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)
Dissociation of Phospho-Nlp from the centrosome (Sus scrofa)
Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)
Authored
Matthews, L (2008-11-11)
Reviewed
Merdes, A (2008-11-17)
Created
Matthews, L (2008-11-11)
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