Reactome | CEP135 [cytosol]

CEP135 [cytosol]

Stable Identifier

R-HSA-380266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep135

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP135 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q66GS9 CEP135

Gene Names

CEP135, CEP4, KIAA0635

Chain

chain:1-1140

Reference Genes

BioGPS Gene:9662 CEP135

COSMIC (genes):CEP135 CEP135

CTD Gene:9662 CEP135

dbSNP Gene:9662 CEP135

ENSEMBL:ENSG00000174799 CEP135

ENSEMBL_homo_sapiens_GENE:ENSG00000174799.12 CEP135

HGNC:29086 CEP135

KEGG Gene (Homo sapiens):9662 CEP135

Monarch:9662 CEP135

NCBI Gene:9662 CEP135

OMIM:611423 CEP135

UCSC:Q66GS9 CEP135

Reference Transcript

RefSeq:NM_025009.4 CEP135

Other Identifiers

11732601_at

11732602_at

16966971

206003_PM_at

206003_at

207286_3p_at

207286_PM_at

207286_at

2727977

2727978

2727979

2727980

2727981

2727982

2727983

2727984

2727985

2727986

2727988

2727989

2727990

2727992

2727993

2727994

2727995

2727996

2727997

2727998

2727999

2728000

2728001

2728002

2728003

2728005

2728010

2728015

2728016

2728017

2728019

2728020

2728021

38854_at

63742_r_at

8095187

9662

A_14_P135953

A_14_P136833

A_14_P200865

A_23_P18479

A_23_P212792

A_24_P140481

GE81949

GE83041

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0007010

GO:0007099

GO:0008017

GO:0008092

GO:0010457

GO:0015631

GO:0042802

GO:0042803

GO:0043226

GO:0044782

GO:1902857

GO:1904951

HMNXSV003031493

ILMN_1693766

PH_hs_0010886

PH_hs_0035659

TC04000327.hg

g13376528_3p_x_at

g7662215_3p_at

Participates

as a component of

Inferred To

CEP135 [cytosol] (Bos taurus)

CEP135 [cytosol] (Canis familiaris)

CEP135 [cytosol] (Gallus gallus)

CEP135 [cytosol] (Sus scrofa)

Cep135 [cytosol] (Mus musculus)

Cep135 [cytosol] (Rattus norvegicus)

Ghost homologue of CEP135 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_079285.2

OpenTargets

ENSG00000174799

HPA

ENSG00000174799-CEP135

GeneCards

Q66GS9

Ensembl

ENSG00000174799, ENST00000257287, ENSP00000257287, ENST00000422247, ENSP00000412799

PRO

Q66GS9

Pharos - Targets

Q66GS9

Orphanet

21068

PDB

5FCN, 5NG4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.702	8
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.527	3
UniProt:Q07157 TJP1	5	TJP1 [cell junction] (R-HSA-8936023) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [cytosol] (R-HSA-532659)	0.483	2
UniProt:Q9UDY2 TJP2	4	TJP2 [plasma membrane] (R-HSA-351862) TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [cytosol] (R-HSA-2064412) TJP2 [nucleoplasm] (R-HSA-2064410)	0.483	3
UniProt:Q15058 KIF14	1	KIF14 [cytosol] (R-HSA-1629804)	0.483	3

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