Loss of Nlp from mitotic centrosomes

Stable Identifier
R-HSA-380259
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Loss of Nlp from mitotic centrosomes
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During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.
Literature References
PubMed ID Title Journal Year
12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

Duncan, PI, Nigg, EA, Weinhart, U, Casenghi, M, Körner, R, Meraldi, P

Dev Cell 2003
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Orthologous Events
Loss of Nlp from mitotic centrosomes (Bos taurus)
Loss of Nlp from mitotic centrosomes (Canis familiaris)
Loss of Nlp from mitotic centrosomes (Gallus gallus)
Loss of Nlp from mitotic centrosomes (Mus musculus)
Loss of Nlp from mitotic centrosomes (Rattus norvegicus)
Loss of Nlp from mitotic centrosomes (Sus scrofa)
Loss of Nlp from mitotic centrosomes (Xenopus tropicalis)
Authored
Matthews, L  (2008-11-11)
Reviewed
Merdes, A  (2008-11-17)
Created
Matthews, L  (2008-11-11)
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