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TACR1 [plasma membrane]
Stable Identifier
R-HSA-380103
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Substance P receptor, NK1R_HUMAN, NK1 receptor
Locations in the PathwayBrowser for interactor UniProt:Q8TBA6 GOLGA5
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)
TACR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25103 TACR1
Gene Names
TACR1, NK1R, TAC1R
Chain
chain:1-407
Reference Genes
BioGPS Gene:6869 TACR1
COSMIC (genes):TACR1 TACR1
CTD Gene:6869 TACR1
dbSNP Gene:6869 TACR1
ENSEMBL:ENSG00000115353 TACR1
ENSEMBL_homo_sapiens_GENE:ENSG00000115353.11 TACR1
HGNC:11526 TACR1
KEGG Gene (Homo sapiens):6869 TACR1
Monarch:6869 TACR1
NCBI Gene:6869 TACR1
OMIM:162323 TACR1
UCSC:P25103 TACR1
Reference Transcript
RefSeq:NM_015727.2 TACR1
RefSeq:NM_001058.3 TACR1
Other Identifiers
11730122_at
11730123_a_at
16899401
208048_PM_at
208048_at
208049_PM_s_at
208049_s_at
210637_PM_at
210637_at
230908_PM_at
230908_at
2560525
2560526
2560527
2560528
2560529
2560549
2560574
2560575
2560576
2560577
2560578
2560579
2560580
2560581
35077_at
47806_at
6869
8053266
A_24_P148590
GE58067
GE698210
GO:0002118
GO:0002376
GO:0002687
GO:0003012
GO:0003013
GO:0003014
GO:0003051
GO:0004930
GO:0004995
GO:0005515
GO:0005886
GO:0005929
GO:0006954
GO:0007010
GO:0007018
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007217
GO:0007611
GO:0007616
GO:0008217
GO:0008306
GO:0009582
GO:0009725
GO:0009986
GO:0010193
GO:0010634
GO:0010996
GO:0014070
GO:0014910
GO:0016020
GO:0016496
GO:0022414
GO:0023052
GO:0030425
GO:0032224
GO:0032230
GO:0032355
GO:0032570
GO:0035094
GO:0035106
GO:0036126
GO:0042713
GO:0042755
GO:0043117
GO:0043226
GO:0044297
GO:0045471
GO:0045760
GO:0045777
GO:0045778
GO:0045907
GO:0046887
GO:0048265
GO:0048266
GO:0048660
GO:0048870
GO:0050671
GO:0050679
GO:0050877
GO:0050886
GO:0051496
GO:0051602
GO:0060083
GO:0060089
GO:0061827
GO:0070472
GO:0070474
GO:0071944
GO:0097225
GO:1902093
HMNXSV003027334
HMNXSV003028601
Hs.66072.0.A1_3p_at
ILMN_1680330
ILMN_1747883
ILMN_1786239
M74290_at
PH_hs_0000142
TC02002005.hg
g189213_3p_at
g7669545_3p_a_at
g7669545_3p_at
Participates
as a candidate of
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
as an input of
Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
TACR1:TAC1(58-68) [plasma membrane] (Homo sapiens)
Other forms of this molecule
TACR1 [clathrin-coated endocytic vesicle membrane]
Inferred To
tacr1 [plasma membrane]
(Xenopus tropicalis)
TACR1 [plasma membrane]
(Bos taurus)
TACR1 [plasma membrane]
(Canis familiaris)
TACR1 [plasma membrane]
(Sus scrofa)
ASPR [plasma membrane]
(Gallus gallus)
Tacr1 [plasma membrane]
(Mus musculus)
Tacr1 [plasma membrane]
(Rattus norvegicus)
tkr-1 [plasma membrane]
(Caenorhabditis elegans)
tacr1a [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001049.1
,
NP_056542.1
ZINC - World Drugs
NK1R_HUMAN
Guide to Pharmacology - Targets
360
OpenTargets
ENSG00000115353
ZINC - FDA approved
NK1R_HUMAN
ZINC - Substances
NK1R_HUMAN
ZINC - Biogenic
NK1R_HUMAN
ZINC target
P25103
PRO
P25103
PDB
7RMI
,
6HLO
,
6HLP
,
7RMH
,
2KS9
,
2KSA
,
8U26
,
7RMG
,
6E59
,
7P02
,
2KSB
,
7P00
,
6HLL
ZINC - Investigational
NK1R_HUMAN
GeneCards
P25103
HPA
ENSG00000115353-TACR1
Ensembl
ENSG00000115353
,
ENSP00000303522
,
ENST00000409848
,
ENSP00000386448
,
ENST00000305249
Pharos - Targets
P25103
ZINC - Predictions - Purchasable
NK1R_HUMAN
HMDB Protein
HMDBP07842
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P0B6 CC167
0.556
3
UniProt:Q9BVK8 TM147
0.556
3
UniProt:Q8TBA6 GOLGA5
2
GOLGA5 [transport vesicle]
(R-HSA-8847517)
GOLGA5 [Golgi membrane]
(R-HSA-8847514)
0.527
2
UniProt:O60637 TSN3
0.527
2
UniProt:P0DJD1 RGPD2
0.527
2
UniProt:O95169 NDUFB8
4
NDUFB8 [mitochondrial inner membrane]
(R-HSA-163938)
NDUFB8(1-28) [mitochondrial matrix]
(R-HSA-8986166)
NDUFB8(1-186) [mitochondrial inner membrane]
(R-HSA-8986184)
NDUFB8(1-186) [mitochondrial intermembrane space]
(R-HSA-8986140)
0.527
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.527
2
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.527
3
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.527
2
UniProt:O43674 NDUFB5
1
NDUFB5 [mitochondrial inner membrane]
(R-HSA-163944)
0.527
2
UniProt:Q9GZM5 YIPF3
0.527
2
UniProt:Q6Y1H2 HACD2
1
PTPLB [endoplasmic reticulum membrane]
(R-HSA-5676075)
0.527
2
UniProt:Q68DH5 LMBD2
0.527
2
UniProt:Q6N075 MFSD5
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
2
UniProt:Q9HBH5 RDH14
1
RDH14 [endoplasmic reticulum membrane]
(R-HSA-2980933)
0.527
2
UniProt:Q9BRX8 PXL2A
0.527
2
UniProt:O95858 TSPAN15
2
TSPAN15 [plasma membrane]
(R-HSA-9010043)
TSPAN15 [endoplasmic reticulum lumen]
(R-HSA-9010117)
0.527
2
UniProt:Q5U3C3 TM164
0.527
2
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.527
2
UniProt:Q96A54 ADIPOR1
1
ADIPOR1 [plasma membrane]
(R-HSA-8848544)
0.527
2
UniProt:O43760 SNG2
0.527
2
UniProt:O60427 FADS1
1
FADS1 [endoplasmic reticulum membrane]
(R-HSA-400122)
0.527
2
UniProt:P00395 MT-CO1
1
nascent MT-CO1 [mitochondrial inner membrane]
(R-HSA-164314)
0.527
2
UniProt:P03915 MT-ND5
1
MT-ND5 [mitochondrial inner membrane]
(R-HSA-60565)
0.527
2
UniProt:O75915 ARL6IP5
1
ARL6IP5 [cytosol]
(R-HSA-2980942)
0.527
2
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