Reactome | Tachykinin receptor 1 (NK1) binds to substance P

Tachykinin receptor 1 (NK1) binds to substance P

Stable Identifier

R-HSA-380076

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Tachykinin receptors bind tachykinins (Homo sapiens)
        
        Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)

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Tachykinin receptor 1 (NK1) binds to substance P

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Substance P (Harmar AJ et al, 1986) is an neuropeptide, 11 amino-acids in length, that acts as a neurotransmitter for pain response neurons. It does this by binding to its endogenous receptor neurokinin 1 (NK1R, substance P receptor) which belongs to the tachykinin receptor sub-family of GPCRs (Takeda Y et al, 1991).

Literature References

PubMed ID	Title	Journal	Year
3770210	cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A Going, J, Chapman, K, Pascall, JC, Harmar, AJ, Edwards, CR, Armstrong, A, Curtis, A, Rosie, R, Fink, G	FEBS Lett	1986
1718267	Molecular cloning, structural characterization and functional expression of the human substance P receptor Takeda, J, Krause, JE, Chou, KB, Sachais, BS, Takeda, Y	Biochem Biophys Res Commun	1991