Tachykinin receptor 1 (NK1) binds to substance P

Stable Identifier
R-HSA-380076
Type
Reaction [binding]
Species
Homo sapiens
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Substance P (Harmar AJ et al, 1986) is an neuropeptide, 11 amino-acids in length, that acts as a neurotransmitter for pain response neurons. It does this by binding to its endogenous receptor neurokinin 1 (NK1R, substance P receptor) which belongs to the tachykinin receptor sub-family of GPCRs (Takeda Y et al, 1991).

Literature References
PubMed ID Title Journal Year
1718267 Molecular cloning, structural characterization and functional expression of the human substance P receptor

Takeda, Y, Chou, KB, Takeda, J, Sachais, BS, Krause, JE

Biochem Biophys Res Commun 1991
3770210 cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A

Harmar, AJ, Armstrong, A, Pascall, JC, Chapman, K, Rosie, R, Curtis, A, Going, J, Edwards, CR, Fink, G

FEBS Lett 1986
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