AP-1 stimulates transcription of IGFBP7

Stable Identifier
R-HSA-3797202
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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AP-1 stimulates transcription of IGFBP7
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FOS:JUN (AP-1) transcription factor stimulates the transcription of IGFBP7 gene. IGFBP7 is a component of the senescence-associated secretory phenotype (SASP) and is secreted by senescent melanocytes in which the senescence is induced by the expression of oncogenic BRAF V600E. The BRAF V600E-mediated induction of IGFBP7 expression is AP-1 dependent. The conditioned medium harvested from BRAF V600E senescent melanocytes is able to inhibit cellular proliferation and induce senescence of naive melanocytes only when IGFBP7 is present in the medium (Wajapeyee et al. 2008).

Literature References
PubMed ID Title Journal Year
18267069 Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7

Zhu, X, Wajapeyee, N, Serra, RW, Green, MR, Mahalingam, M

Cell 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-2S-JUN:p-2S,2T-FOS:IGFBP7 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-2S-cJUN:p-2S,2T-cFOS [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-05)
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