FOS:JUN (AP-1) transcription factor stimulates the transcription of IGFBP7 gene. IGFBP7 is a component of the senescence-associated secretory phenotype (SASP) and is secreted by senescent melanocytes in which the senescence is induced by the expression of oncogenic BRAF V600E. The BRAF V600E-mediated induction of IGFBP7 expression is AP-1 dependent. The conditioned medium harvested from BRAF V600E senescent melanocytes is able to inhibit cellular proliferation and induce senescence of naive melanocytes only when IGFBP7 is present in the medium (Wajapeyee et al. 2008).