Reactome | TARS2(1-?) [mitochondrial matrix]

TARS2(1-?) [mitochondrial matrix]

Stable Identifier

R-HSA-379590

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

TARS2, Threonyl-tRNA synthetase 2

Locations in the PathwayBrowser for interactor UniProt:Q15041%20AR6P1

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External Reference Information

External Reference

UniProt:Q9BW92 TARS2

Gene Names

TARS2, TARSL1

Chain

transit peptide:1-, chain:-718

Reference Genes

BioGPS Gene:80222 TARS2

COSMIC (genes):TARS2 TARS2

CTD Gene:80222 TARS2

dbSNP Gene:80222 TARS2

ENSEMBL:ENSG00000143374 TARS2

ENSEMBL_homo_sapiens_GENE:ENSG00000143374.18 TARS2

HGNC:30740 TARS2

KEGG Gene (Homo sapiens):80222 TARS2

Monarch:80222 TARS2

NCBI Gene:80222 TARS2

OMIM:612805 TARS2

UCSC:Q9BW92 TARS2

Reference Transcript

Other Identifiers

11726587_a_at

11747080_a_at

11752407_x_at

16670547

221189_PM_s_at

221189_s_at

2358321

2358322

2358323

2358324

2358325

2358327

2358329

2358330

2358331

2358332

2358335

2358339

2358340

2358341

2358343

2358345

2358346

2358347

2358348

2358350

2358351

2358353

2358354

2358356

2358357

2358358

2358361

70937_at

77221_s_at

77595_at

7905198

80222

A_23_P553

GE83106

GO:0000166

GO:0002161

GO:0003824

GO:0004812

GO:0004829

GO:0005515

GO:0005524

GO:0005575

GO:0005737

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006435

GO:0006520

GO:0016787

GO:0016874

GO:0042802

GO:0042803

GO:0043039

GO:0043226

GO:0070159

GO:0106074

GO:0140053

GO:0140098

HMNXSV003007541

ILMN_1778187

PH_hs_0015020

TC01001187.hg

g13376742_3p_a_at

Cross References

RefSeq

NP_001258825.1, NP_079426.2

OpenTargets

ENSG00000143374

GeneCards

Q9BW92

HPA

ENSG00000143374-TARS2

Ensembl

ENST00000369054, ENST00000369064, ENSG00000143374, ENSP00000358060, ENSP00000358050

PRO

Q9BW92

Pharos - Targets

Q9BW92

Orphanet

23268

HMDB Protein

HMDBP09249

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q16563 SYPL1			0.556	3
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.556	3
UniProt:Q9BYT1 S17A9			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q969L2 MAL2			0.556	3
UniProt:A2RTX5 SYTC2			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q9UBN6 TNFRSF10D	1	TNFRSF10D [plasma membrane] (R-HSA-5633374)	0.556	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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