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SLC6A3 [plasma membrane]
Stable Identifier
R-HSA-379482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sodium dependent Dopamine transporter
Locations in the PathwayBrowser for interactor UniProt:Q5T9L3 WLS
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Dopamine clearance from the synaptic cleft (Homo sapiens)
SLC6A3 binds DRIs (Homo sapiens)
SLC6A3 [plasma membrane] (Homo sapiens)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A3 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)
SLC6A3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01959 SLC6A3
Gene Names
SLC6A3, DAT1
Chain
chain:1-620
Reference Genes
BioGPS Gene:6531 SLC6A3
COSMIC (genes):SLC6A3 SLC6A3
CTD Gene:6531 SLC6A3
dbSNP Gene:6531 SLC6A3
ENSEMBL:ENSG00000142319 SLC6A3
ENSEMBL_homo_sapiens_GENE:ENSG00000142319.18 SLC6A3
ENSEMBL_homo_sapiens_GENE:ENSG00000276996.2 SLC6A3
HGNC:11049 SLC6A3
KEGG Gene (Homo sapiens):6531 SLC6A3
Monarch:6531 SLC6A3
NCBI Gene:6531 SLC6A3
OMIM:126455 SLC6A3
UCSC:Q01959 SLC6A3
Reference Transcript
RefSeq:NM_001044.4 SLC6A3
Other Identifiers
11727356_a_at
11727357_at
11727358_a_at
11727359_at
16993980
206836_PM_at
206836_at
2845929
2845930
2845931
2845932
2845933
2845934
2845936
2845938
2845939
2845940
2845942
2845945
2845946
2845948
2845949
2845950
2845951
2845952
2845955
2845961
2845962
2845963
2845964
36305_at
6531
8110821
A_24_P397435
A_33_P3303772
GE80041
GO:0001504
GO:0002020
GO:0005102
GO:0005215
GO:0005326
GO:0005330
GO:0005334
GO:0005515
GO:0005737
GO:0005886
GO:0006836
GO:0007595
GO:0007608
GO:0007626
GO:0008504
GO:0009410
GO:0009986
GO:0010039
GO:0014070
GO:0015293
GO:0015844
GO:0015872
GO:0015874
GO:0016020
GO:0016600
GO:0021984
GO:0022857
GO:0023052
GO:0030424
GO:0032809
GO:0035094
GO:0035240
GO:0035725
GO:0040018
GO:0042053
GO:0042220
GO:0042416
GO:0042420
GO:0042734
GO:0042995
GO:0043005
GO:0043025
GO:0043176
GO:0043679
GO:0044877
GO:0045121
GO:0045211
GO:0045471
GO:0046872
GO:0048856
GO:0050877
GO:0050890
GO:0051583
GO:0051591
GO:0051620
GO:0051721
GO:0055085
GO:0060134
GO:0071702
GO:0071705
GO:0090494
GO:0098691
GO:1901363
GO:1990384
HMNXSV003011842
M95167_at
PH_hs_0028682
TC05001109.hg
Y10141_s_at
g4507040_3p_at
Participates
as a component of
SLC6A3:DRIs [plasma membrane] (Homo sapiens)
as an input of
SLC6A3 binds DRIs (Homo sapiens)
Other forms of this molecule
SLC6A3 L368Q [plasma membrane]
SLC6A3 L224P [plasma membrane]
SLC6A3 P395L [plasma membrane]
SLC6A3 R521W [plasma membrane]
Inferred To
SLC6A3 [plasma membrane]
(Bos taurus)
SLC6A3 [plasma membrane]
(Caenorhabditis elegans)
SLC6A3 [plasma membrane]
(Canis familiaris)
SLC6A3 [plasma membrane]
(Drosophila melanogaster)
SLC6A3 [plasma membrane]
(Mus musculus)
SLC6A3 [plasma membrane]
(Rattus norvegicus)
SLC6A3 [plasma membrane]
(Sus scrofa)
slc6a3 [plasma membrane]
(Danio rerio)
slc6a3 [plasma membrane]
(Xenopus tropicalis)
SLC6A6 [plasma membrane]
(Plasmodium falciparum)
Homologues of SLC6A6 [plasma membrane]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001035.1
ZINC - World Drugs
SC6A3_HUMAN
Guide to Pharmacology - Targets
927
OpenTargets
ENSG00000142319
ZINC - FDA approved
SC6A3_HUMAN
ZINC - Substances
SC6A3_HUMAN
ZINC - Biogenic
SC6A3_HUMAN
ZINC target
Q01959
PRO
Q01959
ZINC - Investigational
SC6A3_HUMAN
ZINC - Metabolites
SC6A3_HUMAN
GeneCards
Q01959
HPA
ENSG00000142319-SLC6A3
Ensembl
ENSP00000270349
,
ENSP00000479597
,
ENST00000621716
,
ENSG00000142319
,
ENSG00000276996
,
ENST00000270349
Pharos - Targets
Q01959
Orphanet
19492
ZINC - Predictions - Purchasable
SC6A3_HUMAN
HMDB Protein
HMDBP02547
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9EP80 Pick1
3
Pick1 [plasma membrane]
(R-RNO-8858476)
PICK1 [endocytic vesicle membrane]
(R-RNO-417017)
PICK1 [plasma membrane]
(R-RNO-416989)
0.558
2
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.543
4
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.539
3
UniProt:Q5T9L3 WLS
5
WLS [extracellular exosome]
(R-HSA-3781960)
WLS [endocytic vesicle membrane]
(R-HSA-3781954)
WLS [early endosome membrane]
(R-HSA-3247745)
WLS [Golgi membrane]
(R-HSA-3247747)
WLS [plasma membrane]
(R-HSA-3247746)
0.524
2
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.524
2
UniProt:Q5BJQ5 Rit2
1
GTP-binding protein Rit2 [plasma membrane]
(R-RNO-187749)
0.524
2
UniProt:P14416 DRD2
1
DRD2 [plasma membrane]
(R-HSA-390816)
0.524
4
UniProt:Q99578 RIT2
1
RIT2 [plasma membrane]
(R-HSA-187712)
0.505
5
UniProt:Q5T9L3-1 WLS
0.488
2
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