3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).
DEEDS, F, BOOTH, AN, JONES, FT
methyltransferase activity of COMT [plasma membrane]
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