COMT transfers Met to DOPAC to form HVA

Stable Identifier
R-HSA-379464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
ReviewStatus
5/5
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COMT transfers Met to DOPAC to form HVA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).
Literature References
PubMed ID Title Journal Year
13416264 Methylation and dehydroxylation of phenolic compounds by rats and rabbits

DEEDS, F, BOOTH, AN, JONES, FT

J. Biol. Chem. 1957
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methyltransferase activity of COMT [plasma membrane]

Physical Entity
COMT [plasma membrane] (Homo sapiens)
Activity
methyltransferase activity (GO:0008168)
Orthologous Events
COMT transfers Met to DOPAC to form HVA (Bos taurus)
COMT transfers Met to DOPAC to form HVA (Canis familiaris)
COMT transfers Met to DOPAC to form HVA (Danio rerio)
COMT transfers Met to DOPAC to form HVA (Gallus gallus)
COMT transfers Met to DOPAC to form HVA (Mus musculus)
COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)
COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)
COMT transfers Met to DOPAC to form HVA (Sus scrofa)
COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-30)
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