COMT transfers Met to DOPAC to form HVA

Stable Identifier
R-HSA-379464
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
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3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).

Literature References
PubMed ID Title Journal Year
13416264 Methylation and dehydroxylation of phenolic compounds by rats and rabbits

DEEDS, F, BOOTH, AN, JONES, FT

J. Biol. Chem. 1957
Participants
Participates
Catalyst Activity

methyltransferase activity of COMT [plasma membrane]

Orthologous Events
Authored
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