COMT transfers Met to DOPAC to form HVA

Stable Identifier
R-HSA-379464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
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COMT transfers Met to DOPAC to form HVA
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3,4-dihydroxyphenylacetic acid (DOPAC), generated after oxidative deamination of dopamine by monoamine oxidase A (MAOA), is methylated by catecholamine O-methyltransferase (COMT) to homovanillic acid (HVA) (Deeds et al.1957).

Literature References
PubMed ID Title Journal Year
13416264 Methylation and dehydroxylation of phenolic compounds by rats and rabbits

DEEDS, F, BOOTH, AN, JONES, FT

J. Biol. Chem. 1957
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of COMT [plasma membrane]
Physical Entity
COMT [plasma membrane]
Activity
methyltransferase activity (0008168)
Orthologous Events
COMT transfers Met to DOPAC to form HVA (Canis familiaris)
COMT transfers Met to DOPAC to form HVA (Danio rerio)
COMT transfers Met to DOPAC to form HVA (Gallus gallus)
COMT transfers Met to DOPAC to form HVA (Mus musculus)
COMT transfers Met to DOPAC to form HVA (Plasmodium falciparum)
COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)
COMT transfers Met to DOPAC to form HVA (Schizosaccharomyces pombe)
COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-30)
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