Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid

Stable Identifier
R-HSA-379464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
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3,4-dihydroxyphenylacetic acid, generated after oxidation of dopamine by monoamineoxidase, is methylated by catecholamine o-methyltransferase to homovanillic acid (Deeds et al.1957).

Literature References
PubMed ID Title Journal Year
13416264 Methylation and dehydroxylation of phenolic compounds by rats and rabbits

DEEDS, F, BOOTH, AN, JONES, FT

J. Biol. Chem. 1957
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of COMT [plasma membrane]
Physical Entity
COMT [plasma membrane]
Activity
methyltransferase activity (0008168)
Orthologous Events
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Bos taurus)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Canis familiaris)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Danio rerio)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Gallus gallus)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Mus musculus)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Rattus norvegicus)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Schizosaccharomyces pombe)
Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-30)