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Enzymatic degradation of Dopamine by monoamine oxidase
Stable Identifier
R-HSA-379398
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Dopamine clearance from the synaptic cleft (Homo sapiens)
Enzymatic degradation of Dopamine by monoamine oxidase (Homo sapiens)
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Alternately dopamine is metabolized to homovanillic acid in a two-step reaction in which dopamine is first oxidized to 3,4-dihydroxypheylacetic acid (DOPAC) and then converted to homovanillic acid by catecholamine o-methyltransferase.
Participants
Events
MAOA:FAD deaminates DA to DOPAC
(Homo sapiens)
COMT transfers Met to DOPAC to form HVA
(Homo sapiens)
Participates
as an event of
Dopamine clearance from the synaptic cleft (Homo sapiens)
Event Information
Go Biological Process
dopamine catabolic process (0042420)
Orthologous Events
Enzymatic degradation of Dopamine by monoamine oxidase (Bos taurus)
Enzymatic degradation of Dopamine by monoamine oxidase (Canis familiaris)
Enzymatic degradation of Dopamine by monoamine oxidase (Danio rerio)
Enzymatic degradation of Dopamine by monoamine oxidase (Dictyostelium discoideum)
Enzymatic degradation of Dopamine by monoamine oxidase (Gallus gallus)
Enzymatic degradation of Dopamine by monoamine oxidase (Mus musculus)
Enzymatic degradation of Dopamine by monoamine oxidase (Rattus norvegicus)
Enzymatic degradation of Dopamine by monoamine oxidase (Schizosaccharomyces pombe)
Enzymatic degradation of Dopamine by monoamine oxidase (Sus scrofa)
Enzymatic degradation of Dopamine by monoamine oxidase (Xenopus tropicalis)
Reviewed
Restituito, S (2008-11-27)
Created
Mahajan, SS (2008-10-18)
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