MAOA:FAD deaminates DA to DOPAC

Stable Identifier
R-HSA-379382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)
ReviewStatus
5/5
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MAOA:FAD deaminates DA to DOPAC
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Dopamine (DA) is oxidatively deaminated to 3,4-dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase A (MAOA), bound to its cofactor FAD (O'Caroll et al.1983).
Literature References
PubMed ID Title Journal Year
6408492 The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions

Tipton, KF, O'Carroll, AM, Phillips, JP, Tobbia, I, Fowler, CJ

Naunyn Schmiedebergs Arch Pharmacol 1983
Participants
Input
Output
Participates
as an event of
Catalyst Activity

primary methylamine oxidase activity of MAOA:FAD [mitochondrial outer membrane]

Physical Entity
MAOA:FAD [mitochondrial outer membrane] (Homo sapiens)
Activity
primary methylamine oxidase activity (GO:0008131)
Orthologous Events
MAOA:FAD deaminates DA to DOPAC (Bos taurus)
MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
MAOA:FAD deaminates DA to DOPAC (Gallus gallus)
MAOA:FAD deaminates DA to DOPAC (Mus musculus)
MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)
MAOA:FAD deaminates DA to DOPAC (Sus scrofa)
Authored
Mahajan, SS  (2008-06-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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