Reactome | FSHB [extracellular region]

FSHB [extracellular region]

Stable Identifier

R-HSA-378993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Follitropin subunit beta, FSHB_HUMAN

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Hormone ligand-binding receptors (Homo sapiens)
        
        Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)
        
        FSHR:Follitropin [plasma membrane] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)
        
        Follitropin [extracellular region] (Homo sapiens)
        
        FSHB [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01225 FSHB

Gene Names

FSHB

Chain

signal peptide:1-18, chain:19-129

Reference Genes

BioGPS Gene:2488 FSHB

COSMIC (genes):FSHB FSHB

CTD Gene:2488 FSHB

dbSNP Gene:2488 FSHB

ENSEMBL:ENSG00000131808 FSHB

HGNC:3964 FSHB

KEGG:hsa:2488 FSHB

Monarch:2488 FSHB

NCBI Gene:2488 FSHB

OMIM:136530 FSHB

UCSC:P01225 FSHB

Reference Transcript

Other Identifiers

11737929_a_at

11737930_a_at

16723169

214489_PM_at

214489_at

230_s_at

2488

3325029

3325030

3325031

3325032

3325033

3325034

7939080

A_14_P133221

A_23_P203318

A_33_P3298326

GE896841

GO:0001541

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006355

GO:0006629

GO:0006701

GO:0007179

GO:0007186

GO:0007283

GO:0007292

GO:0007565

GO:0008284

GO:0010469

GO:0010628

GO:0010893

GO:0016913

GO:0016914

GO:0022414

GO:0030335

GO:0042699

GO:0045670

GO:0045780

GO:0045944

GO:0048018

GO:0048856

GO:0060011

GO:0098772

HMNXSV003027113

Hs.36975.0.S1_3p_at

ILMN_1718877

ILMN_2415393

M54914_s_at

PH_hs_0002923

PH_hs_0039183

TC11000294.hg

Participates

as an input of

Follitropin is a heterodimer (Homo sapiens)

as a component of

Follitropin [extracellular region] (Homo sapiens)

Inferred To

FSH beta [extracellular region] (Gallus gallus)

FSHB [extracellular region] (Bos taurus)

FSHB [extracellular region] (Canis familiaris)

FSHB [extracellular region] (Sus scrofa)

Fshb [extracellular region] (Mus musculus)

Fshb [extracellular region] (Rattus norvegicus)

Gpb5 [extracellular region] (Drosophila melanogaster)

gplb-1 [extracellular region] (Caenorhabditis elegans)

lhb [extracellular region] (Danio rerio)

fshb [extracellular region] (Danio rerio)

fshb [extracellular region] (Xenopus tropicalis)

Homologues of FSHB [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_000501.1, NP_001018090.1

ENSEMBL

ENSP00000254122, ENST00000533718, ENSP00000416606, ENSP00000433424, ENST00000254122, ENST00000417547

OpenTargets

ENSG00000131808

HPA

ENSG00000131808-FSHB

PRO

P01225

Pharos - Targets

P01225

GlyGen

P01225

Orphanet

FSHB

PDB

8I2G, 1FL7, 1XWD, 4MQW, 4AY9

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01215 CGA	3	CGA [extracellular region] (R-HSA-378967) CGA [Golgi lumen] (R-HSA-6793928) S-glyco-CGA [Golgi lumen] (R-HSA-6793933)	0.756	4
UniProt:P23945-1 FSHR			0.544	2