Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PCSK1 [secretory granule lumen]
Stable Identifier
R-HSA-378951
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Neuroendocrine convertase 1, NEC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
PCSK1 [secretory granule lumen] (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
PCSK1 [secretory granule lumen] (Homo sapiens)
Insulin processing (Homo sapiens)
PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
PCSK1 [secretory granule lumen] (Homo sapiens)
Peptide hormone biosynthesis (Homo sapiens)
Corticotropin cleavage from POMC (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
PCSK1 [secretory granule lumen] (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
PCSK1 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29120 PCSK1
Gene Names
PCSK1, NEC1
Chain
signal peptide:1-27, propeptide:28-110, chain:111-753
Reference Genes
BioGPS Gene:5122 PCSK1
COSMIC (genes):PCSK1 PCSK1
CTD Gene:5122 PCSK1
dbSNP Gene:5122 PCSK1
ENSEMBL:ENSG00000175426 PCSK1
HGNC:8743 PCSK1
KEGG:hsa:5122 PCSK1
Monarch:5122 PCSK1
NCBI Gene:5122 PCSK1
OMIM:162150 PCSK1
UCSC:P29120 PCSK1
Reference Transcript
RefSeq:NM_001177875.1 PCSK1
RefSeq:NM_000439.4 PCSK1
Other Identifiers
11736339_a_at
11736340_a_at
11756720_a_at
16998342
205825_PM_at
205825_at
2868045
2868046
2868047
2868048
2868050
2868052
2868053
2868054
2868055
2868057
2868060
2868061
2868064
2868065
2868066
2868067
2868069
2868070
2868071
2868072
2868073
40649_at
5122
8113234
A_23_P213508
A_24_P174793
GE59910
GO:0003824
GO:0004175
GO:0004252
GO:0005615
GO:0005737
GO:0005802
GO:0006508
GO:0007267
GO:0008236
GO:0009410
GO:0009749
GO:0010157
GO:0014070
GO:0016020
GO:0016485
GO:0016486
GO:0016540
GO:0016787
GO:0021983
GO:0022008
GO:0023052
GO:0030070
GO:0030133
GO:0030141
GO:0030154
GO:0030425
GO:0031016
GO:0031410
GO:0031667
GO:0032496
GO:0034774
GO:0042802
GO:0043005
GO:0043025
GO:0043043
GO:0043204
GO:0043226
GO:0043231
GO:0043434
GO:0043679
GO:0048471
GO:0048678
GO:0048856
GO:0050714
GO:0051384
GO:0051592
GO:0051604
GO:0070542
GO:0070555
GO:0140096
HMNXSV003025228
ILMN_1710859
ILMN_2081813
PH_hs_0027701
TC05001614.hg
TC05003154.hg
X64810_at
g4585713_3p_at
g4585713_3p_x_at
Participates
as a component of
PC1:calcium cofactor [secretory granule lumen] (Homo sapiens)
Inferred To
PCSK1 [secretory granule lumen]
(Bos taurus)
PCSK1 [secretory granule lumen]
(Canis familiaris)
PCSK1 [secretory granule lumen]
(Gallus gallus)
PCSK1 [secretory granule lumen]
(Sus scrofa)
Pcsk1 [secretory granule lumen]
(Mus musculus)
Pcsk1 [secretory granule lumen]
(Rattus norvegicus)
pcsk1 [secretory granule lumen]
(Danio rerio)
Cross References
RefSeq
NP_000430.3
,
NP_001171346.1
Guide to Pharmacology - Targets
2382
ENSEMBL
ENST00000508626
,
ENSP00000308024
,
ENSP00000421600
,
ENSG00000175426
,
ENST00000311106
OpenTargets
ENSG00000175426
ZINC - Substances
NEC1_HUMAN
ZINC target
P29120
PRO
P29120
GlyGen
P29120
GeneCards
PCSK1
HPA
ENSG00000175426-PCSK1
Pharos - Targets
P29120
Orphanet
PCSK1
ZINC - Predictions - Purchasable
NEC1_HUMAN
HMDB Protein
HMDBP07838
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text