EHMT1:EHMT2 methylates IL6 promoter

Stable Identifier
R-HSA-3788748
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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EHMT1:EHMT2 methylates IL6 promoter
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EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases dimethylate histone H3 (HIST1H3A) on lysine residue 10, creating an H3K9Me2 mark on nucleosomes associated with the IL6 promoter (Takahashi et al. 2012).

Literature References
PubMed ID Title Journal Year
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Takahashi, A, Imai, Y, Yamakoshi, K, Kuninaka, S, Ohtani, N, Yoshimoto, S, Hori, S, Tachibana, M, Anderton, E, Takeuchi, T, Shinkai, Y, Peters, G, Saya, H, Hara, E

Mol. Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
Physical Entity
EHMT1:EHMT2 [nucleoplasm]
Activity
histone-lysine N-methyltransferase activity (0018024)
Orthologous Events
EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)
EHMT1:EHMT2 methylates IL6 promoter (Danio rerio)
EHMT1:EHMT2 methylates IL6 promoter (Drosophila melanogaster)
EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)
EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-04)
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