EHMT1:EHMT2 methylates IL6 promoter

Stable Identifier
R-HSA-3788748
Type
Reaction
Species
Homo sapiens
Compartment
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EHMT1 (GLP) and EHMT2 (G9a) histone methyltransferases dimethylate histone H3 (HIST1H3A) on lysine residue 10, creating an H3K9Me2 mark on nucleosomes associated with the IL6 promoter (Takahashi et al. 2012).

Literature References
PubMed ID Title Journal Year
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E

Mol. Cell 2012
Participants
Participates
Catalyst Activity

histone-lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]

Orthologous Events
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