Reactome | Cdh1:APC/C complex binds EHMT1:EHMT2

Cdh1:APC/C complex binds EHMT1:EHMT2

Stable Identifier

R-HSA-3788725

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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Cdh1 (FZR1) is able to bind both G9a (EHMT2) and GLP (EHMT1) (Takahashi et al. 2012). EHMT1 and EHMT2 histone methyltransferases were shown to function as a heterodimer in vivo (Tachibana et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
22178396	DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells Takahashi, A, Imai, Y, Yamakoshi, K, Kuninaka, S, Ohtani, N, Yoshimoto, S, Hori, S, Tachibana, M, Anderton, E, Takeuchi, T, Shinkai, Y, Peters, G, Saya, H, Hara, E	Mol. Cell	2012
15774718	Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9 Tachibana, M, Ueda, J, Fukuda, M, Takeda, N, Ohta, T, Iwanari, H, Sakihama, T, Kodama, T, Hamakubo, T, Shinkai, Y	Genes Dev.	2005