TP53 binds the CDKN1A promoter

Stable Identifier
R-HSA-3786258
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TP53 (p53), stabilized by ATM-mediated phosphorylation on S15 (Karlseder et al. 1999) binds CDKN1A (p21) promoter (El-Deiry et al. 1993).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B

Cell 1993
10037601 p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

Karlseder, J, Broccoli, D, Dai, Y, Hardy, S, de Lange, T

Science 1999
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