The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double-strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).
Arbel-Eden, A, Haber, JE, Ira, G, Bonner, WM, Shroff, R, Petrini, JH, Pilch, D, Lichten, M
Paull, TT, Lee, JH
Lisby, M, Burgess, RC, Barlow, JH, Rothstein, R
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