MRN complex binds DNA double strand breaks

Stable Identifier
R-HSA-3785768
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MRN complex binds DNA double strand breaks
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The MRN complex (MRE11A:RAD50:NBN) binds to DNA ends found at double-strand breaks (DNA DSBs) (Lee and Paull 2005). In budding yeast, the Mre11:Rad50:Xrs2 complex, homologous to human MRN, rapidly localizes to DNA breaks (Shroff et al. 2004, Lisby et al. 2004).
Literature References
PubMed ID Title Journal Year
15458641 Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

Arbel-Eden, A, Haber, JE, Ira, G, Bonner, WM, Shroff, R, Petrini, JH, Pilch, D, Lichten, M

Curr. Biol. 2004
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Paull, TT, Lee, JH

Science 2005
15369670 Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

Lisby, M, Burgess, RC, Barlow, JH, Rothstein, R

Cell 2004
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Orthologous Events
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MRN complex binds DNA double strand breaks (Rattus norvegicus)
MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)
MRN complex binds DNA double strand breaks (Sus scrofa)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Borowiec, JA  (2015-06-12)
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-04)
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