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Go!
DNA DSBs:MRN [nucleoplasm]
Stable Identifier
R-HSA-3785763
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
KAT5 acetylates ATM at DNA DSBs (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN activates ATM (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN complex binds DNA double strand breaks (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to DNA ends recruits ATM (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates NBN (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
Sensing of DNA Double Strand Breaks (Homo sapiens)
KAT5 acetylates ATM at DNA DSBs (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN activates ATM (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN complex binds DNA double strand breaks (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to DNA ends recruits ATM (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN complex binds RBBP8 (Homo sapiens)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15790808
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
Paull, TT
,
Lee, JH
Science
2005
Participants
components
DNA double-strand break ends [nucleoplasm]
MRN [nucleoplasm]
(Homo sapiens)
Participates
as a component of
DNA DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
as an input of
MRN complex binds RBBP8 (Homo sapiens)
MRN complex bound to DNA ends recruits ATM (Homo sapiens)
as an output of
MRN complex binds DNA double strand breaks (Homo sapiens)
Inferred To
DNA DSBs:MRN [nucleoplasm]
(Bos taurus)
DNA DSBs:MRN [nucleoplasm]
(Caenorhabditis elegans)
DNA DSBs:MRN [nucleoplasm]
(Canis familiaris)
DNA DSBs:MRN [nucleoplasm]
(Dictyostelium discoideum)
DNA DSBs:MRN [nucleoplasm]
(Drosophila melanogaster)
DNA DSBs:MRN [nucleoplasm]
(Gallus gallus)
DNA DSBs:MRN [nucleoplasm]
(Mus musculus)
DNA DSBs:MRN [nucleoplasm]
(Rattus norvegicus)
DNA DSBs:MRN [nucleoplasm]
(Saccharomyces cerevisiae)
DNA DSBs:MRN [nucleoplasm]
(Schizosaccharomyces pombe)
DNA DSBs:MRN [nucleoplasm]
(Sus scrofa)
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