SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of glutamate and cysteine. Under physiological conditions, cytosolic glutamate concentrations are high and cysteine concentrations are low, so glutamate is exported and cysteine imported. SLC7A11 is widely expressed in the body (Bassi et al. 2001; Gasol et al. 2004).

Literature References
PubMed ID Title Journal Year
15151999 Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility

Chillarón, J, Palacin, M, Jiménez-Vidal, M, Gasol, E, Zorzano, A

J Biol Chem 2004
11417227 Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-

Borsani, G, Martin, R, Manzoni, M, Palacin, M, Gasol, E, Bassi, MT, Zorzano, A, Riboni, M, Pineda, M

Pflugers Arch 2001
Catalyst Activity

amino acid transmembrane transporter activity of SLC7A11:SLC3A2 heterodimer [plasma membrane]

Orthologous Events
Cite Us!