Reactome | SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

Stable Identifier

R-HSA-378513

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

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SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of glutamate and cysteine. Under physiological conditions, cytosolic glutamate concentrations are high and cysteine concentrations are low, so glutamate is exported and cysteine imported. SLC7A11 is widely expressed in the body (Bassi et al. 2001; Gasol et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15151999	Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility Chillarón, J, Palacin, M, Jiménez-Vidal, M, Gasol, E, Zorzano, A	J Biol Chem	2004
11417227	Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc- Borsani, G, Martin, R, Manzoni, M, Palacin, M, Gasol, E, Bassi, MT, Zorzano, A, Riboni, M, Pineda, M	Pflugers Arch	2001