SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate

Stable Identifier
R-HSA-378513
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC7A11 as a heterodimer with SLC3A2 in the plasma membrane mediates the exchange of glutamate and cysteine. Under physiological conditions, cytosolic glutamate concentrations are high and cysteine concentrations are low, so glutamate is exported and cysteine imported. SLC7A11 is widely expressed in the body (Bassi et al. 2001; Gasol et al. 2004).

Literature References
PubMed ID Title Journal Year
11417227 Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-

Bassi, MT, Gasol, E, Manzoni, M, Pineda, M, Riboni, M, Martin, R, Zorzano, A, Borsani, G, Palacin, M

Pflugers Arch 2001
15151999 Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility

Gasol, E, Jiménez-Vidal, M, Chillarón, J, Zorzano, A, Palacin, M

J Biol Chem 2004
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Participant Of
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC7A11:SLC3A2 heterodimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
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