HDAC10 is a class IIb HDAC subfamily member with greatest sequence similarity to HDAC6. Unlike HDAC6, HDAC10 is found in the nucleus. It is able to deacetylate acetylated histone H4 N-terminal peptides (Fischer et al. 2002, Guardiola & Yao 2002, Kao et al. 2002, Tong et al. 2002).