Reactome | WNTs are secreted in exosomes

WNTs are secreted in exosomes

Stable Identifier

R-HSA-3781941

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular exosome, endocytic vesicle membrane

ReviewStatus

5/5

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Exsomes have been shown to be involved in secretion of WNTs from HEK293 cells as well as from the human colon cancer cell line Caco2 (Gross et al, 2012). In addition, exosomes from cancer-associated fibroblasts have been shown to promote autocrine PCP signaling and protrusive activity and motility in breast cancer cells (Korkut et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
22983114	Active Wnt proteins are secreted on exosomes Gross, JC, Chaudhary, V, Bartscherer, K, Boutros, M	Nat. Cell Biol.	2012
19837038	Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless Korkut, C, Ataman, B, Ramachandran, P, Ashley, J, Barria, R, Gherbesi, N, Budnik, V	Cell	2009