WNTs are secreted in exosomes

Stable Identifier
R-HSA-3781941
Type
Reaction [omitted]
Species
Homo sapiens
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Exsomes have been shown to be involved in secretion of WNTs from HEK293 cells as well as from the human colon cancer cell line Caco2 (Gross et al, 2012). In addition, exosomes from cancer-associated fibroblasts have been shown to promote autocrine PCP signaling and protrusive activity and motility in breast cancer cells (Korkut et al, 2009).

Literature References
PubMed ID Title Journal Year
19837038 Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless

Korkut, C, Ataman, B, Ramachandran, P, Ashley, J, Barria, R, Gherbesi, N, Budnik, V

Cell 2009
22983114 Active Wnt proteins are secreted on exosomes

Gross, JC, Chaudhary, V, Bartscherer, K, Boutros, M

Nat. Cell Biol. 2012
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