EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex

Stable Identifier
R-HSA-3781021
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
4/5
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EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex
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EPM2A (laforin) dimer binds to the PPP1R3C:phosphoglycogen-GYG2 (glycogenin 2) complex, probably through interactions with the PPP1R3C (PTG) and glycogen moieties of the complex (Worby et al. 2008). This reaction is inferred from the properties of the better studied muscle glycogen particles containing GYG1 (glycogenin 1), and from the fact that in the absence of EMP2A (laforin) function, liver glycogen particles become abnormal in the same way as do muscle particles.
Literature References
PubMed ID Title Journal Year
18070875 Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)

Gentry, MS, Worby, CA, Dixon, JE

J. Biol. Chem. 2008
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Catalyst Activity

protein-macromolecule adaptor activity of PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol]

Physical Entity
PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] (Homo sapiens)
Activity
protein-macromolecule adaptor activity (GO:0030674)
Authored
D'Eustachio, P  (2013-07-19)
Reviewed
Jassal, B  (2013-07-26)
Pederson, B  (2014-02-19)
Created
D'Eustachio, P  (2013-06-28)
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