Reactome | K48polyUb-EPM2A [cytosol]

K48polyUb-EPM2A [cytosol]

Stable Identifier

R-HSA-3781004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48polyUb-Laforin

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Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15930137	Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin Gentry, MS, Worby, CA, Dixon, JE	Proc. Natl. Acad. Sci. U.S.A.	2005

External Reference Information

External Reference

UniProt:O95278 EPM2A

Gene Names

EPM2A

Chain

chain:1-331

Reference Genes

BioGPS Gene:7957 O952786

COSMIC (genes):EPM2A EPM2A

CTD Gene:7957 EPM2A

dbSNP Gene:7957 EPM2A

ENSEMBL:ENSG00000112425 EPM2A

HGNC:3413 O952786

KEGG:hsa:7957 O952786

Monarch:7957 O952786

NCBI Gene:7957 O952786

OMIM:607566 O952786

UCSC:O95278 O952786

Reference Transcript

Participates

as an output of

Other forms of this molecule

EPM2A [cytosol]

EPM2A P301L [cytosol]

EPM2A T194I [cytosol]

EPM2A F84L [cytosol]

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001018051.1, XP_011534418.1, XP_016866791.1, NP_001346986.1, NP_001355060.1, XP_054212402.1, XP_054212403.1, NP_001355061.1, XP_024302319.1, XP_054212405.1, XP_054212404.1, XP_047275320.1, XP_054212398.1, NP_005661.1, XP_006715627.1, NP_001347000.1, NP_001346993.1, XP_016866790.1, XP_016866789.1, NP_001355058.1

OpenTargets

ENSG00000112425

ENSEMBL

ENST00000638778, ENSP00000491180, ENST00000367519, ENSP00000405913, ENSP00000491353, ENST00000611340, ENST00000639465, ENST00000639423, ENST00000638783, ENSG00000112425, ENSP00000480268, ENSP00000491338, ENST00000638262, ENST00000435470, ENSP00000492701, ENSP00000492876, ENSP00000356489

HPA

ENSG00000112425-EPM2A

GeneCards

EPM2A

ZINC - Substances

EPM2A_HUMAN

ZINC target

O95278

PRO

O95278

Pharos - Targets

O95278

Orphanet

EPM2A

PDB

4RKK, 4R30

HMDB Protein

HMDBP01891

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6VVB1 NHLRC1	3	NHLRC1 F33S [cytosol] (R-HSA-3797218) NHLRC1 C26S [cytosol] (R-HSA-3797231) NHLRC1 [cytosol] (R-HSA-3781020)	0.786	8
UniProt:Q9UQK1 PPP1R3C	2	K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005) PPP1R3C [cytosol] (R-HSA-3777102)	0.567	5
UniProt:O95210 STBD1	3	STBD1 [ficolin-1-rich granule membrane] (R-HSA-6801519) STBD1 [plasma membrane] (R-HSA-6801561) STBD1 [tertiary granule membrane] (R-HSA-6801484)	0.527	3

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