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K48polyUb-EPM2A [cytosol]
Stable Identifier
R-HSA-3781004
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48polyUb-Laforin
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
K48polyUb-EPM2A [cytosol] (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)
K48polyUb-EPM2A [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15930137
Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin
Gentry, MS
,
Worby, CA
,
Dixon, JE
Proc. Natl. Acad. Sci. U.S.A.
2005
External Reference Information
External Reference
UniProt:O95278 EPM2A
Gene Names
EPM2A
Chain
chain:1-331
Reference Genes
BioGPS Gene:7957 O952786
COSMIC (genes):EPM2A EPM2A
CTD Gene:7957 EPM2A
dbSNP Gene:7957 EPM2A
ENSEMBL:ENSG00000112425 EPM2A
HGNC:3413 O952786
KEGG:hsa:7957 O952786
Monarch:7957 O952786
NCBI Gene:7957 O952786
OMIM:607566 O952786
UCSC:O95278 O952786
Reference Transcript
RefSeq:XM_024446551.2 O952786
RefSeq:XM_017011300.1 O952786
RefSeq:XM_054356427.1 O952786
RefSeq:XM_011536116.2 O952786
RefSeq:XM_006715564.3 O952786
RefSeq:NM_001368132.1 O952786
RefSeq:XM_054356430.1 O952786
RefSeq:NM_001360071.2 O952786
RefSeq:XM_054356429.1 O952786
RefSeq:NM_001360064.2 O952786
RefSeq:XM_047419364.1 O952786
RefSeq:XM_054356423.1 O952786
RefSeq:NM_001368129.2 O952786
RefSeq:NM_001368131.1 O952786
RefSeq:XM_017011301.1 O952786
RefSeq:XM_054356428.1 O952786
RefSeq:XM_017011302.2 O952786
RefSeq:NM_001018041.2 O952786
RefSeq:NM_005670.4 O952786
RefSeq:NM_001360057.2 O952786
Participates
as an output of
NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 (Homo sapiens)
NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2 (Homo sapiens)
Other forms of this molecule
EPM2A [cytosol]
EPM2A P301L [cytosol]
EPM2A T194I [cytosol]
EPM2A F84L [cytosol]
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001018051.1
,
XP_011534418.1
,
XP_016866791.1
,
NP_001346986.1
,
NP_001355060.1
,
XP_054212402.1
,
XP_054212403.1
,
NP_001355061.1
,
XP_024302319.1
,
XP_054212405.1
,
XP_054212404.1
,
XP_047275320.1
,
XP_054212398.1
,
NP_005661.1
,
XP_006715627.1
,
NP_001347000.1
,
NP_001346993.1
,
XP_016866790.1
,
XP_016866789.1
,
NP_001355058.1
OpenTargets
ENSG00000112425
ENSEMBL
ENST00000638778
,
ENSP00000491180
,
ENST00000367519
,
ENSP00000405913
,
ENSP00000491353
,
ENST00000611340
,
ENST00000639465
,
ENST00000639423
,
ENST00000638783
,
ENSG00000112425
,
ENSP00000480268
,
ENSP00000491338
,
ENST00000638262
,
ENST00000435470
,
ENSP00000492701
,
ENSP00000492876
,
ENSP00000356489
HPA
ENSG00000112425-EPM2A
GeneCards
EPM2A
ZINC - Substances
EPM2A_HUMAN
ZINC target
O95278
PRO
O95278
Pharos - Targets
O95278
Orphanet
EPM2A
PDB
4RKK
,
4R30
HMDB Protein
HMDBP01891
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6VVB1 NHLRC1
3
NHLRC1 F33S [cytosol]
(R-HSA-3797218)
NHLRC1 C26S [cytosol]
(R-HSA-3797231)
NHLRC1 [cytosol]
(R-HSA-3781020)
0.786
8
UniProt:Q9UQK1 PPP1R3C
2
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
PPP1R3C [cytosol]
(R-HSA-3777102)
0.567
5
UniProt:O95210 STBD1
3
STBD1 [ficolin-1-rich granule membrane]
(R-HSA-6801519)
STBD1 [plasma membrane]
(R-HSA-6801561)
STBD1 [tertiary granule membrane]
(R-HSA-6801484)
0.527
3
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