Reactome | H2O2 diffuses from the mitochondrial matrix to the cytosol

H2O2 diffuses from the mitochondrial matrix to the cytosol

Stable Identifier

R-HSA-3779381

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix, mitochondrial inner membrane

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H2O2 diffuses from the mitochondrial matrix to the cytosol

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As inferred from rat heart mitochondria, hydrogen peroxide is released from mitochondria at a rate that is dependent on the membrane potential. Knockdown of Aquaporin-8 (AQP8) in human cells indicates that hydrogen peroxide is able to transit through the water channel of AQP8 located in the inner mitochodrial membrane (Marchissio et al. 2012). The resulting level of cytosolic hydrogen peroxide is hypothesized to signal the state of the mitochondria to regulatory molecules in the cytosol and nucleus (reviewed in Antico Arciuch et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
21967640	Mitochondrial regulation of cell cycle and proliferation Poderoso, JJ, Carreras, MC, Antico Arciuch, VG, Elguero, ME	Antioxid. Redox Signal.	2012
22910329	Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability Marinelli, RA, Marchissio, MJ, Francés, DE, Carnovale, CE	Toxicol. Appl. Pharmacol.	2012
22493009	Site of mitochondrial reactive oxygen species production in skeletal muscle of chronic obstructive pulmonary disease and its relationship with exercise oxidative stress Puente-Maestu, L, Simón, C, Agustí, A, Alvarez-Sala, L, Tejedor, A, González-Aragoneses, F, de Miguel, J, Lázaro, A	Am. J. Respir. Cell Mol. Biol.	2012