H2O2 diffuses from the mitochondrial matrix to the cytosol

Stable Identifier
R-HSA-3779381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix, mitochondrial inner membrane
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H2O2 diffuses from the mitochondrial matrix to the cytosol
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As inferred from rat heart mitochondria, hydrogen peroxide is released from mitochondria at a rate that is dependent on the membrane potential. Knockdown of Aquaporin-8 (AQP8) in human cells indicates that hydrogen peroxide is able to transit through the water channel of AQP8 located in the inner mitochodrial membrane (Marchissio et al. 2012). The resulting level of cytosolic hydrogen peroxide is hypothesized to signal the state of the mitochondria to regulatory molecules in the cytosol and nucleus (reviewed in Antico Arciuch et al. 2012).

Literature References
PubMed ID Title Journal Year
22910329 Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

Marchissio, MJ, Francés, DE, Carnovale, CE, Marinelli, RA

Toxicol. Appl. Pharmacol. 2012
21967640 Mitochondrial regulation of cell cycle and proliferation

Antico Arciuch, VG, Elguero, ME, Poderoso, JJ, Carreras, MC

Antioxid. Redox Signal. 2012
22493009 Site of mitochondrial reactive oxygen species production in skeletal muscle of chronic obstructive pulmonary disease and its relationship with exercise oxidative stress

Puente-Maestu, L, Tejedor, A, Lázaro, A, de Miguel, J, Alvarez-Sala, L, González-Aragoneses, F, Simón, C, Agustí, A

Am. J. Respir. Cell Mol. Biol. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
channel activity of AQP8 tetramer [mitochondrial inner membrane]
Physical Entity
AQP8 tetramer [mitochondrial inner membrane]
Activity
channel activity (0015267)
Inferred From
H2O2 diffuses from the mitochondrial matrix to the cytosol (Rattus norvegicus)
Authored
May, B  (2013-06-26)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-27)