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PPP2R2A [cytosol]
Stable Identifier
R-HSA-377253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2A-regulatory subunit B55 alpha isoform
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
PPP2R2A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63151 PPP2R2A
Gene Names
PPP2R2A
Chain
initiator methionine:, chain:2-447
Reference Genes
BioGPS Gene:5520 PPP2R2A
COSMIC (genes):PPP2R2A PPP2R2A
CTD Gene:5520 PPP2R2A
dbSNP Gene:5520 PPP2R2A
ENSEMBL:ENSG00000221914 PPP2R2A
ENSEMBL_homo_sapiens_GENE:ENSG00000221914.11 PPP2R2A
HGNC:9304 PPP2R2A
KEGG Gene (Homo sapiens):5520 PPP2R2A
Monarch:5520 PPP2R2A
NCBI Gene:5520 PPP2R2A
OMIM:604941 PPP2R2A
UCSC:P63151 PPP2R2A
Reference Transcript
RefSeq:NM_001177591.1 PPP2R2A
RefSeq:NM_002717.3 PPP2R2A
Other Identifiers
11756714_a_at
1383_at
202313_PM_at
202313_at
228013_PM_at
228013_at
3090938
3090939
3090940
3090941
3090943
3090944
3090956
3090961
3090964
3090967
3090972
3090973
3090975
3090982
3090983
3090988
3090989
3090990
3090991
3090992
3090993
3090994
3487899
41167_at
46187_at
5520
8145440
82421_i_at
82422_r_at
A_14_P123050
A_23_P123539
A_24_P346644
GE58038
GO:0000159
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006470
GO:0019888
GO:0036211
GO:0043226
GO:0043278
GO:0045202
GO:0098772
GO:0098978
HMNXSV003024886
Hs.61696.0.A1_3p_at
ILMN_1788961
M64929_at
PH_hs_0028631
g4506018_3p_at
p33838
Participates
as an input of
PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
as a component of
p-S26-ANXA2:PPP2R2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
Other forms of this molecule
PPP2R2A [nucleoplasm]
Inferred To
tws [cytosol]
(Drosophila melanogaster)
phr2aB [cytosol]
(Dictyostelium discoideum)
CDC55 [cytosol]
(Saccharomyces cerevisiae)
pab1 [cytosol]
(Schizosaccharomyces pombe)
sur-6 [cytosol]
(Caenorhabditis elegans)
ppp2r2a [cytosol]
(Xenopus tropicalis)
Ghost homologue of PPP2R2A [cytosol]
(Plasmodium falciparum)
PPP2R2A [cytosol]
(Bos taurus)
PPP2R2A [cytosol]
(Canis familiaris)
PPP2R2A [cytosol]
(Gallus gallus)
PPP2R2A [cytosol]
(Sus scrofa)
Ppp2r2a [cytosol]
(Mus musculus)
Ppp2r2a [cytosol]
(Rattus norvegicus)
ppp2r2ab [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001171062.1
,
NP_002708.1
OpenTargets
ENSG00000221914
GeneCards
P63151
HPA
ENSG00000221914-PPP2R2A
ZINC target
P63151
Ensembl
ENSG00000221914
,
ENST00000380737
,
ENST00000315985
,
ENSP00000325074
,
ENSP00000370113
PRO
P63151
Pharos - Targets
P63151
PDB
3DW8
,
8TTB
,
8SO0
,
8TWE
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.953
20
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.915
12
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.886
8
UniProt:P30154 PPP2R1B
2
PPP2R1B [cytosol]
(R-HSA-165980)
PPP2R1B [nucleoplasm]
(R-HSA-166000)
0.727
5
UniProt:Q9BXL8 CDCA4
0.671
6
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.671
7
UniProt:Q76MZ3 Ppp2r1a
2
Ppp2r1a [nucleoplasm]
(R-MMU-165968)
PP2A A subunit [cytosol]
(R-MMU-206067)
0.669
3
UniProt:Q96E09 PBIR1
0.643
4
UniProt:Q9NUC0 SRTD4
0.643
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.641
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
16
UniProt:P53355 DAPK1
1
DAPK1 [cytosol]
(R-HSA-418262)
0.593
3
UniProt:Q99958 FOXC2
1
FOXC2 [nucleoplasm]
(R-HSA-3927898)
0.564
2
UniProt:Q8NE08 Q8NE08
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9NZR2 LRP1B
0.556
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.556
3
UniProt:Q9BTL4 IER2
0.527
4
UniProt:Q8IVT5 KSR1
5
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
p-S311,Y602 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y602 KSR1 [cytosol]
(R-HSA-5672656)
0.527
2
UniProt:Q12950 FOXD4
0.527
4
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
2
UniProt:Q12948 FOXC1
1
FOXC1 [nucleoplasm]
(R-HSA-3927815)
0.527
2
UniProt:Q96IG2 FBXL20
1
FBXL20 [cytosol]
(R-HSA-8862591)
0.463
4
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.462
2
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