Reactome | NDE1 [cytosol]

NDE1 [cytosol]

Stable Identifier

R-HSA-376257

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        NDE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NXR1 NDE1

Gene Names

NDE1, NUDE

Chain

chain:1-335

Reference Genes

BioGPS Gene:54820 NDE1

COSMIC (genes):NDE1 NDE1

CTD Gene:54820 NDE1

dbSNP Gene:54820 NDE1

ENSEMBL:ENSG00000072864 NDE1

ENSEMBL_homo_sapiens_GENE:ENSG00000072864.16 NDE1

ENSEMBL_homo_sapiens_GENE:ENSG00000275911.3 NDE1

HGNC:17619 NDE1

KEGG Gene (Homo sapiens):54820 NDE1

Monarch:54820 NDE1

NCBI Gene:54820 NDE1

OMIM:609449 NDE1

Reference Transcript

Other Identifiers

11725110_a_at

11725111_at

11725112_at

11756077_a_at

16816200

218414_PM_s_at

218414_s_at

222625_PM_s_at

222625_s_at

230219_PM_at

230219_at

239307_PM_at

239307_at

3649812

3649813

3649814

3649815

3649821

3649822

3649823

3649827

3649831

3649832

3649833

3649836

3649848

3649849

3649850

3649856

3649857

3649858

3649860

43376_at

45364_at

45365_g_at

54820

7993467

84271_r_at

A_23_P206901

A_24_P210675

A_32_P15898

GE82201

GO:0000132

GO:0000278

GO:0000775

GO:0000776

GO:0001764

GO:0005515

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005886

GO:0007010

GO:0007018

GO:0007020

GO:0007049

GO:0007059

GO:0007100

GO:0007163

GO:0007399

GO:0007405

GO:0008017

GO:0008092

GO:0016020

GO:0016477

GO:0021987

GO:0030154

GO:0030900

GO:0031023

GO:0031616

GO:0032154

GO:0042802

GO:0043226

GO:0045202

GO:0047496

GO:0048856

GO:0048870

GO:0051298

GO:0051301

GO:0051303

GO:0051642

GO:0065003

GO:0140014

HMNXSV003005363

HMNXSV003015595

HMNXSV003015915

HMNXSV003026620

HMNXSV003057023

Hs.263925.0.S1_3p_a_at

Hs.263925.0.S1_3p_x_at

Hs.263925.1.A1_3p_at

Hs.308305.0.A1_3p_at

ILMN_1739805

PH_hs_0013649

TC16000192.hg

g8923109_3p_a_at

p6298

Participates

as a component of

Inferred To

Nde1 [cytosol] (Mus musculus)

Nde1 [cytosol] (Rattus norvegicus)

nde1 [cytosol] (Xenopus tropicalis)

NDE1 [cytosol] (Bos taurus)

NDE1 [cytosol] (Canis familiaris)

NDE1 [cytosol] (Gallus gallus)

NDE1 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016878845.1, NP_001137451.1, XP_016878838.1, NP_060138.1

OpenTargets

ENSG00000072864

GeneCards

Q9NXR1

HPA

ENSG00000072864-NDE1

Ensembl

ENSP00000379643, ENSP00000501936, ENST00000675926, ENSP00000379642, ENST00000396354, ENST00000396355, ENSG00000072864, ENSP00000488050, ENSP00000488199, ENST00000674554, ENSP00000502160, ENST00000631923, ENST00000675951, ENST00000631844, ENSP00000502635, ENSP00000502354, ENST00000674888, ENSG00000275911

PRO

Q9NXR1

Pharos - Targets

Q9NXR1

Orphanet

20548

PDB

7E1T

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:P63005	1	Pafah1b1 [cytosol] (R-MMU-376249)	0.564	2
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.508	2

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