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KIF2C [cytosol]
Stable Identifier
R-HSA-376256
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MCAK
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Kinesins (Homo sapiens)
Kinesin-13 is a dimer (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinesin-13 monomers [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinesins bind microtubules (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinesins move along microtubules consuming ATP (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
Kinesins:microtubule [cytosol] (Homo sapiens)
Kinesins [cytosol] (Homo sapiens)
Kinesin-13 dimers [cytosol] (Homo sapiens)
MCAK dimer [cytosol] (Homo sapiens)
KIF2C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99661 KIF2C
Gene Names
KIF2C, KNSL6
Chain
initiator methionine:, chain:2-725
Reference Genes
BioGPS Gene:11004 KIF2C
COSMIC (genes):KIF2C KIF2C
CTD Gene:11004 KIF2C
dbSNP Gene:11004 KIF2C
ENSEMBL:ENSG00000142945 KIF2C
ENSEMBL_homo_sapiens_GENE:ENSG00000142945.13 KIF2C
HGNC:6393 KIF2C
KEGG Gene (Homo sapiens):11004 KIF2C
Monarch:11004 KIF2C
NCBI Gene:11004 KIF2C
OMIM:604538 KIF2C
UCSC:Q99661 KIF2C
Reference Transcript
RefSeq:NM_001297657.1 KIF2C
RefSeq:NM_006845.3 KIF2C
RefSeq:NM_001297655.1 KIF2C
RefSeq:NM_001297656.1 KIF2C
Other Identifiers
11004
11729623_a_at
11745868_a_at
16663958
209408_PM_at
209408_at
211519_PM_s_at
211519_s_at
2334099
2334100
2334103
2334105
2334106
2334107
2334110
2334111
2334112
2334113
2334114
2334116
2334118
2334119
2334120
2334122
2334125
2334126
2334127
2334129
2334133
2334134
2334135
2334136
2334137
2334138
2334139
2334140
36837_at
7901010
A_14_P109506
A_14_P134166
A_23_P34788
GE59302
GO:0000166
GO:0000278
GO:0000775
GO:0000776
GO:0003677
GO:0003774
GO:0003777
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005871
GO:0005874
GO:0005881
GO:0007010
GO:0007018
GO:0007019
GO:0007049
GO:0007059
GO:0007080
GO:0007163
GO:0008017
GO:0008092
GO:0015630
GO:0016020
GO:0016787
GO:0016887
GO:0019237
GO:0030951
GO:0035371
GO:0043226
GO:0051010
GO:0051301
GO:0051310
GO:0051315
GO:0051983
GO:0140014
GO:0140657
HMNXSV003036846
ILMN_1685916
PH_hs_0004101
TC01000563.hg
U63743_at
g13432054_3p_a_at
g1695881_3p_at
Participates
as a member of
Kinesin-13 monomers [cytosol] (Homo sapiens)
as a component of
MCAK dimer [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Inferred To
KIF2C [cytosol]
(Caenorhabditis elegans)
KIF2C [cytosol]
(Canis familiaris)
KIF2C [cytosol]
(Drosophila melanogaster)
KIF2C [cytosol]
(Gallus gallus)
KIF2C [cytosol]
(Mus musculus)
KIF2C [cytosol]
(Rattus norvegicus)
KIF2C [cytosol]
(Sus scrofa)
Ghost homologue of KIF2C [cytosol]
(Bos taurus)
Ghost homologue of KIF2C [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001284584.1
,
NP_006836.2
,
NP_001284586.1
,
NP_001284585.1
OpenTargets
ENSG00000142945
HPA
ENSG00000142945-KIF2C
GeneCards
Q99661
ZINC target
Q99661
Ensembl
ENSP00000361298
,
ENSG00000142945
,
ENSP00000361291
,
ENST00000372224
,
ENST00000372217
PRO
Q99661
Pharos - Targets
Q99661
PDB
4UBF
,
2HEH
,
4Y05
,
5MIO
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.499
4
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