DSCAM directly binds to serine/threonine-protein kinase PAK1 and this interaction is enhanced by the presence of Rac1 protein. Rac1 interacts with the CRIB motif in the N-terminal domain of PAK1 and DSCAM interacts with the kinase domain of PAK1. Rac1-bound PAK1, which is already active, has higher affinity for DSCAM, which may further regulate PAK1 activation.
Guan, KL, Li, W
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