Reactome | DSCAM/DSCAML1 homodimerization

DSCAM/DSCAML1 homodimerization

Stable Identifier

R-HSA-376122

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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DSCAM and DSCAML1 proteins are involved in homophilic intercellular interactions and these recognition events may play a role in neural connectivity. Recent studies in mouse demonstrate that DSCAM is selectively expressed in subclasses of cells and suggest that it uses homophilic repulsion to simultaneously promote both self avoidance (an essential developmental mechanism that allows axonal and dendrite processes to uniformly cover their synaptic fields) and tiling (ensures that the receptive fields of neurons from the same class do not overlap with one another) (Fuerst et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18216855	Neurite arborization and mosaic spacing in the mouse retina require DSCAM Burgess, RW, Masland, RH, Koizumi, A, Fuerst, PG	Nature	2008
18216854	Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina Sanes, JR, Yamagata, M	Nature	2008
10925149	Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion Agarwala, KL, Yamakawa, K, Tsutsumi, Y, Nakamura, S	Brain Res Mol Brain Res	2000
11453658	Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion Ganesh, S, Agarwala, KL, Yamakawa, K, Amano, K, Suzuki, T, Tsutsumi, Y	Biochem Biophys Res Commun	2001