SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-375487
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine
ReviewStatus
5/5
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SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol
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SLC6A14, associated with the plasma membrane, mediates the uptake of multiple basic and nonpolar amino acids as well as beta-alanine. Uptake of one amino acid molecule is accompanied by uptake of two sodium ions and a chloride ion. As assessed by Northern blotting, SLC6A14 is expressed at high levels in lung but only at low levels, if at all, in intestine or kidney (Sloan & Mager 1999, Anderson et al. 2008).
Literature References
PubMed ID Title Journal Year
10446133 Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)

Sloan, JL, Mager, S

J Biol Chem 1999
18599538 Human solute carrier SLC6A14 is the {beta}-alanine carrier

Anderson, CM, Ganapathy, V, Thwaites, DT

J Physiol 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC6A14 [plasma membrane]

Physical Entity
SLC6A14 [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Danio rerio)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-08-30)
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