SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-375487
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine
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SLC6A14, associated with the plasma membrane, mediates the uptake of multiple basic and nonpolar amino acids as well as beta-alanine. Uptake of one amino acid molecule is accompanied by uptake of two sodium ions and a chloride ion. As assessed by Northern blotting, SLC6A14 is expressed at high levels in lung but only at low levels, if at all, in intestine or kidney (Sloan & Mager 1999, Anderson et al. 2008).

Literature References
PubMed ID Title Journal Year
10446133 Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)

Sloan, JL, Mager, S

J Biol Chem 1999
18599538 Human solute carrier SLC6A14 is the {beta}-alanine carrier

Anderson, CM, Ganapathy, V, Thwaites, DT

J Physiol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC6A14 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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