Reactome | SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-375487

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine

ReviewStatus

5/5

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SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol

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SLC6A14, associated with the plasma membrane, mediates the uptake of multiple basic and nonpolar amino acids as well as beta-alanine. Uptake of one amino acid molecule is accompanied by uptake of two sodium ions and a chloride ion. As assessed by Northern blotting, SLC6A14 is expressed at high levels in lung but only at low levels, if at all, in intestine or kidney (Sloan & Mager 1999, Anderson et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18599538	Human solute carrier SLC6A14 is the {beta}-alanine carrier Thwaites, DT, Ganapathy, V, Anderson, CM	J Physiol	2008
10446133	Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+) Mager, S, Sloan, JL	J Biol Chem	1999