Reactome | Bombesin-like receptors bind bombesin homologues

Bombesin-like receptors bind bombesin homologues

Stable Identifier

R-HSA-375384

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Bombesin-like receptors bind bombesin homologues

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Bombesin-like receptors are widely distributed in the CNS as well as in the GI tract where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behaviour through the binding of bombesin-like peptides. They include gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R) (Corjay MH et al, 1991) and bombesin-like receptor-3 (BRS-3) (Fathi Z et al, 1993). BRS-3 binds bombesin peptides with low affinity and is often classed as an orphan receptor. There are two homologues of bombesin-like peptides; Gastrin-releasing peptide (GRP) (Sausville EA et al, 1986) and Neuromedin-B (NMB) (Krane IM et al, 1988). GRP regulates gastric acid secretion and motor function and is a negative feedback operator regulating fear. NMB is involved in the regulation of many functions such as cell growth, body temperature and blood pressure and glucose levels.

Literature References

PubMed ID	Title	Journal	Year
1655761	Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells Battey, JF, Worland, P, Viallet, J, Dobrzanski, DJ, Shapira, H, Way, JM, Corjay, MH, Sausville, EA	J Biol Chem	1991
8383682	BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells Battey, JF, Benya, R, Viallet, J, Wada, E, Shapira, H, Fathi, Z, Corjay, MH, Sausville, EA, Jensen, R	J Biol Chem	1993