Reactome | GRP(24-50) [extracellular region]

GRP(24-50) [extracellular region]

Stable Identifier

R-HSA-375358

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Gastrin-releasing peptide, GRP_HUMAN, GRP

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bombesin-like receptors bind bombesin homologues (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like peptide [extracellular region] (Homo sapiens)
        
        GRP(24-50) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07492 GRP

Gene Names

GRP

Chain

signal peptide:1-23, peptide:24-50, peptide:41-50, propeptide:54-148

Reference Genes

BioGPS Gene:2922 GRP

COSMIC (genes):GRP GRP

CTD Gene:2922 GRP

dbSNP Gene:2922 GRP

ENSEMBL:ENSG00000134443 GRP

ENSEMBL_homo_sapiens_GENE:ENSG00000134443.10 GRP

HGNC:4605 GRP

KEGG Gene (Homo sapiens):2922 GRP

Monarch:2922 GRP

NCBI Gene:2922 GRP

OMIM:137260 GRP

UCSC:P07492 GRP

Reference Transcript

Other Identifiers

11756874_a_at

16852676

206326_PM_at

206326_at

272_at

273_g_at

2922

3790530

3790531

3790535

3790536

3790540

3790541

8021461

A_14_P102673

A_23_P101131

GE57535

GO:0002376

GO:0005102

GO:0005184

GO:0005515

GO:0005576

GO:0005615

GO:0007165

GO:0007218

GO:0016192

GO:0023052

GO:0031410

GO:0034774

GO:0035176

GO:0036343

GO:0042995

GO:0043005

GO:0043207

GO:0043226

GO:0043303

GO:0048018

GO:0055085

GO:0090277

GO:0098772

GO:0098992

GO:1900738

GO:1903817

GO:1903942

GO:1905151

GO:2000987

HMNXSV003048831

ILMN_1777199

ILMN_2413323

K02054_at

PH_hs_0022695

TC18000211.hg

TC18000740.hg

g4504158_3p_at

Participates

as a member of

Bombesin-like peptide [extracellular region] (Homo sapiens)

This entity regulates

Positively

Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)

Inferred To

GRP [extracellular region] (Bos taurus)

GRP [extracellular region] (Canis familiaris)

GRP [extracellular region] (Gallus gallus)

GRP [extracellular region] (Sus scrofa)

Grp [extracellular region] (Mus musculus)

Grp [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001012530.1, NP_001012531.1, NP_002082.2

OpenTargets

ENSG00000134443

GeneCards

P07492

HPA

ENSG00000134443-GRP

Ensembl

ENST00000529320, ENSP00000256857, ENST00000420468, ENSP00000434101, ENSG00000134443, ENST00000256857, ENSP00000389696

PRO

P07492

Pharos - Targets

P07492

PDB

2N0B, 2N0H, 2N0C, 2N0G, 2N0E, 2N0F, 2N0D, 7W3Z

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15699 ALX1			0.556	3