Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GRP(24-50) [extracellular region]
Stable Identifier
R-HSA-375358
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Gastrin-releasing peptide, GRP_HUMAN, GRP
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Bombesin-like receptors bind bombesin homologues (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
Bombesin-like peptide [extracellular region] (Homo sapiens)
GRP(24-50) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07492 GRP
Gene Names
GRP
Chain
signal peptide:1-23, peptide:24-50, peptide:41-50, propeptide:54-148
Reference Genes
BioGPS Gene:2922 GRP
COSMIC (genes):GRP GRP
CTD Gene:2922 GRP
dbSNP Gene:2922 GRP
ENSEMBL:ENSG00000134443 GRP
HGNC:4605 GRP
KEGG:hsa:2922 GRP
Monarch:2922 GRP
NCBI Gene:2922 GRP
OMIM:137260 GRP
UCSC:P07492 GRP
Reference Transcript
RefSeq:NM_001012513.2 GRP
RefSeq:NM_002091.4 GRP
RefSeq:NM_001012512.2 GRP
Other Identifiers
11756874_a_at
16852676
206326_PM_at
206326_at
272_at
273_g_at
2922
3790530
3790531
3790535
3790536
3790540
3790541
8021461
A_14_P102673
A_23_P101131
GE57535
GO:0001503
GO:0002376
GO:0005102
GO:0005184
GO:0005515
GO:0005576
GO:0005615
GO:0007165
GO:0007218
GO:0010468
GO:0016192
GO:0031410
GO:0034774
GO:0035176
GO:0036343
GO:0042995
GO:0043005
GO:0043207
GO:0043226
GO:0043303
GO:0048018
GO:0090277
GO:0098772
GO:0098992
GO:1900738
GO:1903817
GO:1903942
GO:1904384
GO:1905151
GO:1905461
GO:2000987
HMNXSV003048831
ILMN_1777199
ILMN_2413323
K02054_at
PH_hs_0022695
TC18000211.hg
TC18000740.hg
g4504158_3p_at
Participates
as a member of
Bombesin-like peptide [extracellular region] (Homo sapiens)
This entity regulates
Positively
Glucagon-like Peptide 1 is secreted from intestinal L cells
(Homo sapiens)
Inferred To
GRP [extracellular region]
(Bos taurus)
GRP [extracellular region]
(Canis familiaris)
GRP [extracellular region]
(Gallus gallus)
GRP [extracellular region]
(Sus scrofa)
Grp [extracellular region]
(Mus musculus)
Grp [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001012530.1
,
NP_001012531.1
,
NP_002082.2
ENSEMBL
ENST00000420468
,
ENSP00000256857
,
ENSP00000434101
,
ENST00000529320
,
ENST00000256857
,
ENSP00000389696
OpenTargets
ENSG00000134443
HPA
ENSG00000134443-GRP
PRO
P07492
Pharos - Targets
P07492
GlyGen
P07492
PDB
2N0G
,
2N0F
,
2N0C
,
2N0D
,
2N0H
,
7W3Z
,
2N0B
,
2N0E
,
8H0Q
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15699 ALX1
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text