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C5AR1 [plasma membrane]
Stable Identifier
R-HSA-375356
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C5a anaphylatoxin chemotactic receptor, C5AR_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C5a receptor binds C5a anaphylatoxin (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
C5a receptor binds C5a anaphylatoxin (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
C5AR1:C5a [plasma membrane] (Homo sapiens)
C5AR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21730 C5AR1
Gene Names
C5AR1, C5AR, C5R1
Chain
chain:1-350
Reference Genes
BioGPS Gene:728 C5AR1
COSMIC (genes):C5AR1 C5AR1
CTD Gene:728 C5AR1
dbSNP Gene:728 C5AR1
ENSEMBL:ENSG00000197405 C5AR1
HGNC:1338 C5AR1
KEGG:hsa:728 C5AR1
Monarch:728 C5AR1
NCBI Gene:728 C5AR1
OMIM:113995 C5AR1
UCSC:P21730 C5AR1
Reference Transcript
RefSeq:NM_001736.3 C5AR1
Other Identifiers
11733355_x_at
11733356_at
16863589
220088_PM_at
220088_at
3837256
3837258
3837260
3837261
3837262
3837263
3837264
728
8029907
A_14_P131510
A_23_P153562
A_23_P303058
GE80070
GO:0001774
GO:0002376
GO:0002430
GO:0002682
GO:0004875
GO:0004878
GO:0004930
GO:0005886
GO:0006351
GO:0006935
GO:0006954
GO:0006955
GO:0006968
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007606
GO:0010575
GO:0010759
GO:0016020
GO:0016071
GO:0016323
GO:0030593
GO:0030667
GO:0031410
GO:0032494
GO:0038178
GO:0042789
GO:0043226
GO:0045177
GO:0045766
GO:0048143
GO:0048870
GO:0050679
GO:0050830
GO:0050877
GO:0050890
GO:0060089
GO:0070374
GO:0090023
GO:0097242
GO:0098542
GO:0099172
GO:1902947
HMNXSV003056825
ILMN_1689836
M62505_at
PH_hs_0030878
TC19000676.hg
g4502508_3p_at
Participates
as a member of
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
as an input of
C5a receptor binds C5a anaphylatoxin (Homo sapiens)
as a component of
C5AR1:C5a [plasma membrane] (Homo sapiens)
Other forms of this molecule
C5AR1 [secretory granule membrane]
Inferred To
c3ar1 [plasma membrane]
(Xenopus tropicalis)
C5AR1 [plasma membrane]
(Bos taurus)
C5AR1 [plasma membrane]
(Canis familiaris)
C5AR1 [plasma membrane]
(Gallus gallus)
C5AR1 [plasma membrane]
(Sus scrofa)
C5ar1 [plasma membrane]
(Mus musculus)
C5ar1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001727.1
Guide to Pharmacology - Targets
32
ENSEMBL
ENSP00000347197
,
ENST00000355085
OpenTargets
ENSG00000197405
ZINC - Substances
C5AR1_HUMAN
ZINC target
P21730
PRO
P21730
GlyGen
P21730
PDB
8GO8
,
8HK5
,
6C1R
,
8I0N
,
8I0Z
,
7Y65
,
7Y67
,
8GOO
,
8JZZ
,
6C1Q
,
7Y64
,
8IA2
,
5O9H
,
7Y66
,
2K3U
ZINC - Investigational
C5AR1_HUMAN
HPA
ENSG00000197405-C5AR1
Pharos - Targets
P21730
ZINC - Predictions - Purchasable
C5AR1_HUMAN
HMDB Protein
HMDBP07483
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