Connexin 45/Connexin 36 mediated neuronal gap junction communication

Stable Identifier
R-HSA-375330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Connexin 45/Connexin 36 mediated neuronal gap junction communication
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In this electrical synapse the current generated in the presynaptic cell spreads to the postsynaptic cell through an ion channel composed of two hemi-channels composed of six Connexin 45 proteins on one hemi-channel and six Connexin 36 proteins on the second.
Literature References
PubMed ID Title Journal Year
20930146 Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart

Sasse, P, Maschke, S, de Sevilla Müller, LP, Janssen-Bienhold, U, Dobrowolski, R, Eiberger, B, Kim, JS, Weiler, R, Tjarks, A, Willecke, K, Frank, M, Fleischmann, BK

J. Cell. Sci. 2010
24454290 Connexin and pannexin (hemi)channels in the liver

Rogiers, V, Menezes, GB, Leybaert, L, Mennecier, G, Dagli, ML, Decrock, E, Marques, PE, Oliveira, AG, Vinken, M, Maes, M, Cogliati, B, Vanhaecke, T

Front Physiol 2014
Participants
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Output
Entity On Other Cell
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as an event of
Catalyst Activity

gap junction channel activity of Connexin 36/Connexin 45 Gap Junction Complex [plasma membrane]

Physical Entity
Connexin 36/Connexin 45 Gap Junction Complex [plasma membrane] (Homo sapiens)
Activity
gap junction channel activity (GO:0005243)
Orthologous Events
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Bos taurus)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Gallus gallus)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Sus scrofa)
Connexin 45/Connexin 36 mediated neuronal gap junction communication (Xenopus tropicalis)
Authored
Gillespie, ME  (2009-02-23)
Reviewed
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2008-08-26)
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