Reactome | Connexin 45/Connexin 36 mediated neuronal gap junction communication

Connexin 45/Connexin 36 mediated neuronal gap junction communication

Stable Identifier

R-HSA-375330

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Connexin 45/Connexin 36 mediated neuronal gap junction communication

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In this electrical synapse the current generated in the presynaptic cell spreads to the postsynaptic cell through an ion channel composed of two hemi-channels composed of six Connexin 45 proteins on one hemi-channel and six Connexin 36 proteins on the second.

Literature References

PubMed ID	Title	Journal	Year
20930146	Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart Frank, M, Eiberger, B, Janssen-Bienhold, U, de Sevilla Müller, LP, Tjarks, A, Kim, JS, Maschke, S, Dobrowolski, R, Sasse, P, Weiler, R, Fleischmann, BK, Willecke, K	J. Cell. Sci.	2010
24454290	Connexin and pannexin (hemi)channels in the liver Maes, M, Decrock, E, Cogliati, B, Oliveira, AG, Marques, PE, Dagli, ML, Menezes, GB, Mennecier, G, Leybaert, L, Vanhaecke, T, Rogiers, V, Vinken, M	Front Physiol	2014