Connexin 45/Connexin 36 mediated neuronal gap junction communication

Stable Identifier
R-HSA-375330
Type
Reaction [transition]
Species
Homo sapiens
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In this electrical synapse the current generated in the presynaptic cell spreads to the postsynaptic cell through an ion channel composed of two hemi-channels composed of six Connexin 45 proteins on one hemi-channel and six Connexin 36 proteins on the second.

Literature References
PubMed ID Title Journal Year
24454290 Connexin and pannexin (hemi)channels in the liver

Maes, M, Decrock, E, Cogliati, B, Oliveira, AG, Marques, PE, Dagli, ML, Menezes, GB, Mennecier, G, Leybaert, L, Vanhaecke, T, Rogiers, V, Vinken, M

Front Physiol 2014
20930146 Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart

Frank, M, Eiberger, B, Janssen-Bienhold, U, de Sevilla Müller, LP, Tjarks, A, Kim, JS, Maschke, S, Dobrowolski, R, Sasse, P, Weiler, R, Fleischmann, BK, Willecke, K

J. Cell. Sci. 2010
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Catalyst Activity

gap junction channel activity of Connexin 36/Connexin 45 Gap Junction Complex [plasma membrane]

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