Reactome | NCAM1 binds to ATP

NCAM1 binds to ATP

Stable Identifier

R-HSA-375160

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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NCAM1 has been demonstrated to possess (Ca++ or Mg++) dependant ATP hydrolyzing activity. ATP can bind to NCAM directly and that NCAM can act as an ecto-ATPase hydrolyzing around 1000 molecules of ATP/minute. Binding of ATP to NCAM1 inhibits cellular aggregation and neurite outgrowth induced by NCAM1-FGFR binding. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding.

Literature References

PubMed ID	Title	Journal	Year
9398268	Demonstration of an extracellular ATP-binding site in NCAM: functional implications of nucleotide binding Dzhandzhugazyan, K, Bock, E	Biochemistry	1997
8262246	Demonstration of (Ca(2+)-Mg2+)-ATPase activity of the neural cell adhesion molecule Dzhandzhugazyan, K, Bock, E	FEBS Lett	1993