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NCAM1 binds to ATP
Stable Identifier
R-HSA-375160
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
NCAM1 binds to ATP (Homo sapiens)
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NCAM1 has been demonstrated to possess (Ca++ or Mg++) dependant ATP hydrolyzing activity. ATP can bind to NCAM directly and that NCAM can act as an ecto-ATPase hydrolyzing around 1000 molecules of ATP/minute. Binding of ATP to NCAM1 inhibits cellular aggregation and neurite outgrowth induced by NCAM1-FGFR binding. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding.
Literature References
PubMed ID
Title
Journal
Year
9398268
Demonstration of an extracellular ATP-binding site in NCAM: functional implications of nucleotide binding
Dzhandzhugazyan, K
,
Bock, E
Biochemistry
1997
8262246
Demonstration of (Ca(2+)-Mg2+)-ATPase activity of the neural cell adhesion molecule
Dzhandzhugazyan, K
,
Bock, E
FEBS Lett
1993
Participants
Input
ATP [extracellular region]
NCAM1 [plasma membrane]
(Homo sapiens)
Output
NCAM-1:ATP [plasma membrane]
(Homo sapiens)
Participates
as an event of
NCAM1 interactions (Homo sapiens)
Orthologous Events
NCAM1 binds to ATP (Canis familiaris)
NCAM1 binds to ATP (Mus musculus)
NCAM1 binds to ATP (Rattus norvegicus)
Authored
Garapati, P V (2009-02-24)
Reviewed
Walmod, PS (2009-05-26)
Maness, PF (2009-05-26)
Created
Garapati, P V (2008-08-11)
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