NCAM1 binds to ATP

Stable Identifier
R-HSA-375160
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NCAM1 has been demonstrated to possess (Ca++ or Mg++) dependant ATP hydrolyzing activity. ATP can bind to NCAM directly and that NCAM can act as an ecto-ATPase hydrolyzing around 1000 molecules of ATP/minute. Binding of ATP to NCAM1 inhibits cellular aggregation and neurite outgrowth induced by NCAM1-FGFR binding. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding.

Literature References
PubMed ID Title Journal Year
8262246 Demonstration of (Ca(2+)-Mg2+)-ATPase activity of the neural cell adhesion molecule

Dzhandzhugazyan, K, Bock, E

FEBS Lett 1993
9398268 Demonstration of an extracellular ATP-binding site in NCAM: functional implications of nucleotide binding

Dzhandzhugazyan, K, Bock, E

Biochemistry 1997
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