Reactome | Interaction of NCAM1 with GFRalpha-1

Interaction of NCAM1 with GFRalpha-1

Stable Identifier

R-HSA-375149

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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GFRalpha receptors GFRalpha1 and possibly also GFRalpha2 and GFRalpha4 subunit of the GDNF (glial cell line-derived neurotrophic factor) receptor interact in cis with NCAM and functions as a coreceptor for GDNF in the absence of RET. The NCAM1-GFRalpha1 interaction down regulates NCAM1-mediated cell adhesion and promotes GDNF-NCAM1 binding.

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