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Interaction of NCAM1 with GFRalpha-1
Stable Identifier
R-HSA-375149
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)
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GFRalpha receptors GFRalpha1 and possibly also GFRalpha2 and GFRalpha4 subunit of the GDNF (glial cell line-derived neurotrophic factor) receptor interact in cis with NCAM and functions as a coreceptor for GDNF in the absence of RET. The NCAM1-GFRalpha1 interaction down regulates NCAM1-mediated cell adhesion and promotes GDNF-NCAM1 binding.
Participants
Input
GFRalpha [plasma membrane]
(Homo sapiens)
NCAM1 [plasma membrane]
(Homo sapiens)
Output
NCAM1:GFRalpha-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
NCAM1 interactions (Homo sapiens)
Inferred From
Interaction of NCAM1 with GFRalpha-1 (Rattus norvegicus)
Authored
Garapati, P V (2009-02-24)
Reviewed
Walmod, PS (2009-05-26)
Maness, PF (2009-05-26)
Created
Garapati, P V (2008-08-11)
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