Basigin binds CD98 complex

Stable Identifier
R-HSA-375131
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Basigin binds CD98 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CD97hc is a multifunctional glycoprotein with a single transmembrane domain, is highly expressed on proliferating cells, and functions as a chaperone for transporters. CD98hc forms disulfide-bonded heterodimers with at least seven different light chains (SLC7A5-11) that serve as amino acid transporters. Covalent cross-linking, mass spectrometric protein identification, and co-immunoprecipitation shows selective CD147 association with CD98hc complex.

Literature References
PubMed ID Title Journal Year
15901826 Metabolic activation-related CD147-CD98 complex

Xu, D, Hemler, ME

Mol Cell Proteomics 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Basigin binds CD98 complex (Canis familiaris)
Basigin binds CD98 complex (Danio rerio)
Basigin binds CD98 complex (Gallus gallus)
Basigin binds CD98 complex (Mus musculus)
Basigin binds CD98 complex (Rattus norvegicus)
Basigin binds CD98 complex (Xenopus tropicalis)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2008-08-11)