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About
What is Reactome ?
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Scientific Advisory Board
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Release Calendar
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License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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GDNF [extracellular region]
Stable Identifier
R-HSA-375061
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Glial cell line-derived neurotrophic factor, GDNF_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the ureteric bud (Homo sapiens)
Expression of GDNF in metanephric mesenchyme (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
Expression of WNT11 in the nephric duct (Homo sapiens)
GDNF:RET:GFRA1 [plasma membrane] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
GDNF:RET:GFRA1 [plasma membrane] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)
GDNF family ligands (GFLs) [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
NCAM1:GFRalpha-1:GDNF [plasma membrane] (Homo sapiens)
GDNF family ligands (GFLs) [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-S696-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
RET dimerizes (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
RET tyrosine phosphorylation (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
SHC1 in the RET complex is phosphorylated (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
p-5Y-RET complexes bind GRB2 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
GDNF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39905 GDNF
Gene Names
GDNF
Chain
signal peptide:1-19, propeptide:20-75, chain:78-211
Reference Genes
BioGPS Gene:2668 GDNF
COSMIC (genes):GDNF GDNF
CTD Gene:2668 GDNF
dbSNP Gene:2668 GDNF
ENSEMBL:ENSG00000168621 GDNF
HGNC:4232 GDNF
KEGG:hsa:2668 GDNF
Monarch:2668 GDNF
NCBI Gene:2668 GDNF
OMIM:600837 GDNF
UCSC:P39905 GDNF
Reference Transcript
RefSeq:NM_001190468.1 GDNF
RefSeq:XM_011514030.2 GDNF
RefSeq:NM_001278098.1 GDNF
RefSeq:NM_001190469.1 GDNF
RefSeq:XM_017009337.1 GDNF
RefSeq:NM_199231.2 GDNF
RefSeq:NM_000514.3 GDNF
Participates
as a member of
GDNF family ligands (GFLs) [extracellular region] (Homo sapiens)
GDNF,NRTN [extracellular region] (Homo sapiens)
as an output of
Expression of GDNF in metanephric mesenchyme (Homo sapiens)
as an input of
GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct (Homo sapiens)
as a component of
GDNF:RET:GFRA1 [plasma membrane] (Homo sapiens)
Inferred To
GDNF [extracellular region]
(Bos taurus)
GDNF [extracellular region]
(Canis familiaris)
GDNF [extracellular region]
(Gallus gallus)
GDNF [extracellular region]
(Rattus norvegicus)
GDNF [extracellular region]
(Sus scrofa)
Gdnf [extracellular region]
(Mus musculus)
gdnf [extracellular region]
(Danio rerio)
gdnf [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001265027.1
,
XP_016864826.1
,
NP_001177397.1
,
NP_954701.1
,
NP_000505.1
,
XP_011512332.1
,
NP_001177398.1
OpenTargets
ENSG00000168621
ENSEMBL
ENSP00000339703
,
ENST00000381826
,
ENSP00000409007
,
ENSP00000425928
,
ENSP00000317145
,
ENSP00000371248
,
ENST00000427982
,
ENST00000344622
,
ENST00000620847
,
ENST00000326524
,
ENSP00000478722
,
ENST00000515058
,
ENSG00000168621
HPA
ENSG00000168621-GDNF
GeneCards
GDNF
PRO
P39905
Pharos - Targets
P39905
Orphanet
GDNF
GlyGen
P39905
PDB
4UX8
,
6Q2N
,
3FUB
,
2V5E
HMDB Protein
HMDBP02176
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.488
2
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