Reactome | NPBWR1 [plasma membrane]

NPBWR1 [plasma membrane]

Stable Identifier

R-HSA-374780

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Neuropeptides B/W receptor type 1, NPBW1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)
        
        Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)
        
        Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)
        
        NPBWR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48145 NPBWR1

Gene Names

NPBWR1, GPR7

Chain

chain:1-328

Reference Genes

BioGPS Gene:2831 NPBWR1

COSMIC (genes):NPBWR1 NPBWR1

CTD Gene:2831 NPBWR1

dbSNP Gene:2831 NPBWR1

ENSEMBL:ENSG00000288611 NPBWR1

HGNC:4522 NPBWR1

KEGG:hsa:2831 NPBWR1

Monarch:2831 NPBWR1

NCBI Gene:2831 NPBWR1

OMIM:600730 NPBWR1

UCSC:P48145 NPBWR1

Reference Transcript

RefSeq:NM_005285.3 NPBWR1

Other Identifiers

11743234_at

17068928

231752_PM_at

231752_at

2831

3098214

3098216

3098218

49763_at

8146429

ADDON002735.hg

A_23_P20458

A_33_P3233219

GE553233

GO:0004930

GO:0004985

GO:0005515

GO:0005886

GO:0007186

GO:0007218

GO:0007268

GO:0008188

GO:0016020

GO:0019222

GO:0023052

GO:0038003

GO:0042923

GO:0043005

GO:0045202

GO:0060089

HMNXSV003014596

Hs.248117.0.S1_3p_at

ILMN_1752681

TC08000368.hg

Participates

as a member of

Neuropeptides B/W receptors [plasma membrane] (Homo sapiens)

Inferred To

Npbwr1 [plasma membrane] (Mus musculus)

Npbwr1 [plasma membrane] (Rattus norvegicus)

npbwr1 [plasma membrane] (Xenopus tropicalis)

NPBWR1 [plasma membrane] (Bos taurus)

NPBWR1 [plasma membrane] (Canis familiaris)

NPBWR1 [plasma membrane] (Gallus gallus)

NPBWR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_005276.2

Guide to Pharmacology - Targets

303

ENSEMBL

ENSP00000501711, ENST00000674939, ENSG00000288611

GeneCards

NPBWR1

HPA

ENSG00000288611-NPBWR1

ZINC - Substances

NPBW1_HUMAN

ZINC target

P48145

PRO

P48145

Pharos - Targets

P48145

GlyGen

P48145

ZINC - Predictions - Purchasable

NPBW1_HUMAN