Reactome | SSTR5 [plasma membrane]

SSTR5 [plasma membrane]

Stable Identifier

R-HSA-374753

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Somatostatin receptor type 5, SSR5_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35346 SSTR5

Gene Names

SSTR5

Chain

chain:1-364

Reference Genes

BioGPS Gene:6755 SSTR5

COSMIC (genes):SSTR5 SSTR5

CTD Gene:6755 SSTR5

dbSNP Gene:6755 SSTR5

ENSEMBL:ENSG00000162009 SSTR5

HGNC:11334 SSTR5

KEGG:hsa:6755 SSTR5

Monarch:6755 SSTR5

NCBI Gene:6755 SSTR5

OMIM:182455 SSTR5

UCSC:P35346 SSTR5

Reference Transcript

Other Identifiers

11743223_at

16814577

214555_PM_at

214555_at

3643556

3643557

3643559

3643565

3643566

3643567

3643568

3643569

3643570

3643571

3643572

6755

778_s_at

7992145

A_23_P77545

D16827_s_at

GE546704

GO:0004930

GO:0004994

GO:0005515

GO:0005886

GO:0007186

GO:0007187

GO:0007218

GO:0008285

GO:0016020

GO:0032467

GO:0038170

GO:0042923

GO:0043005

GO:0050796

GO:0060089

GO:0071385

HMNXSV003028517

Hs.241375.0.S1_3p_at

ILMN_1690563

PH_hs_0029475

TC16000035.hg

Participates

as a member of

Somatostatin receptors [plasma membrane] (Homo sapiens)

Inferred To

SSTR5 [plasma membrane] (Bos taurus)

SSTR5 [plasma membrane] (Canis familiaris)

SSTR5 [plasma membrane] (Gallus gallus)

SSTR5 [plasma membrane] (Sus scrofa)

Sstr5 [plasma membrane] (Mus musculus)

Sstr5 [plasma membrane] (Rattus norvegicus)

sstr5 [plasma membrane] (Danio rerio)

sstr5 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001166031.1, NP_001044.1

ZINC - World Drugs

SSR5_HUMAN

Guide to Pharmacology - Targets

359

ENSEMBL

ENSP00000293897, ENSP00000508487, ENST00000293897, ENST00000689027

OpenTargets

ENSG00000162009

ZINC - Substances

SSR5_HUMAN

ZINC target

P35346

PRO

P35346

GlyGen

P35346

PDB

8X8N, 8X8L

ZINC - Investigational

SSR5_HUMAN

HPA

ENSG00000162009-SSTR5

Pharos - Targets

P35346

ZINC - Predictions - Purchasable

SSR5_HUMAN

HMDB Protein

HMDBP14434