Reactome | L1 interaction with Integrins

L1 interaction with Integrins

Stable Identifier

R-HSA-374686

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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L1 can function as a trans-heterophilic ligand for multiple members of the integrin superfamily. It binds multiple integrins including alphavbeta3, alphavbeta1, alpha5beta1, alphaIIbbeta3 and alpha9beta 1. The RGD motif in the sixth Ig domain and the third FnIII repeat of L1 are important for these interactions, which serves to strengthen the adhesion of the neuron to the extracellular matrix.
L1 and beta1 integrins association activates a common intracellular signaling pathway. This pathway involves the sequential activation of the tyrosine kinase c-Src, PI3 kinase, Vav2 guanine nucleotide exchange factor, Rac1 GTPase, PAK1, MEK, and the MAP kinases ERK1/2, which is essential for L1 induced neurite outgrowth and cell motility.

Literature References

PubMed ID	Title	Journal	Year
9396761	A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins Felding-Habermann, B, Silletti, S, Mei, F, Siu, CH, Yip, PM, Brooks, PC, Cheresh, DA, O'Toole, TE, Ginsberg, MH, Montgomery, AM	J Cell Biol	1997
18555990	The RGD integrin binding site in human L1-CAM is important for nuclear signaling Gast, D, Riedle, S, Kiefel, H, Müerköster, SS, Schäfer, H, Schäfer, MK, Altevogt, P	Exp Cell Res	2008