L1 and NCAM1 engaged in cis-interaction

Stable Identifier
R-HSA-374681
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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L1 and NCAM1 engaged in cis-interaction
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L1 and NCAM1 co-expressed on a single cell interact with each other via the fourth Ig domain of NCAM1 and the oligomannose type oligosaccharides carried by L1. This interaction has synergetic effects on L1-mediated cell aggregation and adhesion, a phenomenon referred to as 'assisted homophilic L1-L1 trans-binding'.

Literature References
PubMed ID Title Journal Year
10611478 Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth

Soroka, V, Ronn, LC, Kristiansen, LV, Pedersen, N, Berezin, V, Kiselyov, V, Marques, FA, Bock, E

FEBS Lett 1999
8509458 The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth

Magyar, JP, Horstkorte, R, Vorherr, T, Schmitz, B, Schachner, M

J Cell Biol 1993
2295682 The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions

Kadmon, G, Kowitz, A, Altevogt, P, Schachner, M

J Cell Biol 1990
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Orthologous Events
L1 and NCAM1 engaged in cis-interaction (Caenorhabditis elegans)
L1 and NCAM1 engaged in cis-interaction (Mus musculus)
L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)
L1 and NCAM1 engaged in cis-interaction (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2008-07-30)
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