Reactome | L1 and NCAM1 engaged in cis-interaction

L1 and NCAM1 engaged in cis-interaction

Stable Identifier

R-HSA-374681

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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L1 and NCAM1 co-expressed on a single cell interact with each other via the fourth Ig domain of NCAM1 and the oligomannose type oligosaccharides carried by L1. This interaction has synergetic effects on L1-mediated cell aggregation and adhesion, a phenomenon referred to as 'assisted homophilic L1-L1 trans-binding'.

Literature References

PubMed ID	Title	Journal	Year
8509458	The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth Horstkorte, R, Schachner, M, Magyar, JP, Vorherr, T, Schmitz, B	J Cell Biol	1993
10611478	Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth Kristiansen, LV, Marques, FA, Soroka, V, Ronn, LC, Kiselyov, V, Pedersen, N, Berezin, V, Bock, E	FEBS Lett	1999
2295682	The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions Kadmon, G, Kowitz, A, Altevogt, P, Schachner, M	J Cell Biol	1990