L1 and NCAM1 co-expressed on a single cell interact with each other via the fourth Ig domain of NCAM1 and the oligomannose type oligosaccharides carried by L1. This interaction has synergetic effects on L1-mediated cell aggregation and adhesion, a phenomenon referred to as 'assisted homophilic L1-L1 trans-binding'.
Soroka, V, Ronn, LC, Kristiansen, LV, Pedersen, N, Berezin, V, Kiselyov, V, Marques, FA, Bock, E
Magyar, JP, Horstkorte, R, Vorherr, T, Schmitz, B, Schachner, M
Kadmon, G, Kowitz, A, Altevogt, P, Schachner, M
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